Identification of a Potent and Selective 5-HT6 Antagonist: One-Step Synthesis of (E)-3-(Benzenesulfonyl)-2-
(methylsulfanyl)pyrido[1,2-a]pyrimidin- 4-ylidenamine from 2-(Benzenesulfonyl)-3,3- bis(methylsulfanyl)acrylonitrile …

The aminomethylchroman derivative BAY× 3702 (R-(−)-2-{4-[(chroman-2-ylmethyl)-amino]-
butyl}-1, 1-dioxo-benzo [d] isothiazolone hydrochloride) is a new high affinity 5 …

The indolonaphthyridine 8 is described as a selective 5-HT2C/2B vs 5-HT2A receptor
antagonist. The compound was synthesized in seven steps starting from indolineand …

Monoamine serotonin is a major neurotransmitter that acts on a wide range of central
nervous system and peripheral nervous system functions and is known to have a role in …

Simple syntheses of four new and potent analogues of the 5-HT1A receptor ligand, WAY-
100635 are described, namely the 6-(pyridinyl)-bromo-, the 6-(pyridinyl)-fluoro-, the …

Multiparallel amenable syntheses of 6-methoxy-8-amino-4-oxo-1, 4-dihydroquinoline-2-
carboxylic acid-(4-morpholin-4-yl-phenyl) amides (I) and 4-amino-6-methoxy-8-(4-methyl …

Local delivery of serotonin (5-HT) produces a rapid edematous response in soft tissues via
increased fluid extravasation which is prevented by 5-HT2 antagonists such as ketanserin or …

Serotonin type 3 (5-HT3) receptors are pentameric ion channels belonging to the
superfamily of Cys-loop receptors. Receptor activation either leads to fast excitatory …

The antagonistic properties of DAU 6285, an azabicycloalkyl benzimidazolone derivative, at
putative 5-hydroxytryptamine 4 (5-HT 4) receptors were investigated in in vitro preparations …

Obesity prevalence continues to be a foremost health concern across the globe leading to
the development of major health risk conditions like type II diabetes, hyperlipidemia …