The multidrug efflux system MexXY-OprM, inside the resistance-nodulation-division family, is
a major determinant of aminoglycoside resistance in Pseudomonas aeruginosa. In the fight …

Efflux pumps of the resistance nodulation division (RND) superfamily, such as AcrB, make a
major contribution to multidrug resistance in Gram-negative bacteria. The development of …

Active efflux of antibiotics preventing their accumulation to toxic intracellular concentrations
contributes to clinically relevant multidrug resistance. Inhibition of active efflux potentiates …

The permeability barrier of Gram-negative cell envelopes is the major obstacle in the
discovery and development of new antibiotics. In Gram-negative bacteria, these difficulties …

With the spreading of antibiotic resistance, the translocation of antibiotics through bacterial
envelopes is crucial for their antibacterial activity. In Gram-negative bacteria, the interplay …

Bacterial multidrug resistance (MDR) has become a major public health threat. Along with
enzymatic modifications, overexpression of MDR efflux pumps is a significant antibiotic …

Bacterial multidrug-resistance transporters of the major facilitator superfamily are
distinguished by their extraordinary ability to bind structurally diverse substrates, thus …

Multidrug efflux systems play a prominent role in medicine, as they are important
contributors to bacterial antibiotic resistance. NorA is an efflux pump transporter from the …

Antimicrobial resistance is a key public health concern of our era due to an ever-increasing
number of drug-resistant pathogens, including several Gram-negative bacilli. The latter are …

The AdeABC efflux pump is an important mechanism causing multidrug resistance in
Acinetobacter baumannii, and its main component AdeB can recognize carbapenems …