Expression studies of RBBP6 in breast and cervical cancer suggests a role in apoptosis activation

M Choene, P Moela, L Motadi - Cancer Research, 2016 - AACR
Ubiquitin-like DWNN domain and RING finger-like domain presence on Retinoblastoma
Binding protein 6 (RBBP6), is linked to its function as cancer promoting gene through p53 …

Expression Analysis of RbBP6 in human cancers: a Prospective biomarker

Z Mbita, R Hull, M Mbele, T Makhafola… - Anti-Cancer …, 2019 - journals.lww.com
Abstract Retinoblastoma binding protein 6 (RBBP6) is a cancer-related protein that has
been implicated in the regulation of cell cycle and apoptosis. RBBP6 isoform 1 has been …

RBBP6: a potential biomarker of apoptosis induction in human cervical cancer cell lines

P Moela, LR Motadi - OncoTargets and therapy, 2016 - Taylor & Francis
Overexpression of RBBP6 in cancers of the colon, lung, and esophagus makes it a potential
target in anticancer therapy. This is especially important because RBBP6 associates with the …

De-regulation of the RBBP6 isoform 3/DWNN in human cancers

Z Mbita, M Meyer, A Skepu, M Hosie, J Rees… - Molecular and cellular …, 2012 - Springer
Abstract Retinoblastoma binding protein 6 (RBBP6) is a nuclear protein, previously
implicated in the regulation of cell cycle and apoptosis. The human RBBP6 gene codes for …

RBBP6 is abundantly expressed in human cervical carcinoma and may be implicated in its malignant progression

Z Dlamini, T Ledwaba, R Hull, S Naicker… - Biomarkers in …, 2019 - journals.sagepub.com
RBBP6 is a novel gene encoding splicing-associated proteins. There are 3 protein isoforms
(isoforms 1-3). RBBP6 isoforms 1 has been shown to interact with both p53 and Rb. It also …

RBBP6 expressional effects on cell proliferation and apoptosis in breast cancer cell lines with distinct p53 statuses

LR Motadi, MM Lekganyane… - Cancer Management and …, 2018 - Taylor & Francis
Introduction Breast cancer is the most common malignancy amongst women and has a
higher incidence rate than lung cancer. Its tumor progression partially results from …

Expression analysis and association of RBBP6 with apoptosis in colon cancers

Z Dlamini, C Rupnarain, S Naicker, R Hull… - Journal of molecular …, 2016 - Springer
Apoptosis is normally kept under strict control by a range of regulators and inhibitors, and
loss of this regulation strongly directs tumour progression. The novel RBBP6 gene has been …

[PDF][PDF] Implications of RBBP6 in various types of cancer.

F Khan, M Allam, M Tincho, A Pretorius - IWBBIO, 2014 - academia.edu
Background: The 2 50 k Da r etinoblastoma bi nding pr otein 6 (RBBP6) was cloned over a
decade ago and was found to bind both the p53 and Rb1 tumor suppressor proteins. In …

[PDF][PDF] Silencing of mouse RBBP6 using interference RNA implicates it in apoptosis and the cell cycle

A Pretorius, HA Bankole, M Meyer, F Februar… - GSTF Int …, 2013 - researchgate.net
Retinoblastoma-binding protein 6 (RBBP6) is one of the few proteins that interacts with both
tumour suppressor proteins p53 and Rb and by implication plays an important role in cell …

[PDF][PDF] Functional analysis and characterization of the human RBBP6 promoters based on a combination of molecular biology and in silico approaches provide …

A Pretorius, M Kaur, M Wamalwa, MF February… - J. Biosci, 2013 - academia.edu
Retinoblastoma Binding Protein 6 (RBBP6) has been implicated in the apoptotic pathway
and regulation of the cell cycle through its interaction with p53, Rb and YB1 and …