Objective The extracellular matrix (ECM) of ovarian cancer may provide a number of
potential biomarkers. Chondroitin sulfate (CS), a class of sulfated polysaccharides, is …

OBJECTIVE: Clinical decision making in ovarian cancer needs new (prognostic) biomarkers.
Although the search for biomarkers has traditionally focused on tumor cells, their …

Aims: Ovarian cancer has the highest case-to-fatality-index of all gynecological cancers. In
this study, tumor-related alterations in the extracellular matrix, especially regarding …

Chondroitin sulfate (CS) is abundantly present in the tumor stroma, and tumor-specific CS
modifications might be potential targets to influence tumor development. We applied the …

Considering the high mortality of ovarian cancer, novel approaches for diagnostics and
therapy are urgently needed. Cancer initiation, progression, and invasion occur in a …

Ovarian cancer (OvCa) accounts for the highest tumor-related mortality among
gynecological malignancies, but the underlying mechanisms are poorly understood …

Objective: To determine the value of serum chondroitin sulfate epitope WF6 and hyaluronan
(HA) levels as a biomarker for early detection of ovarian epithelial cancer and other …

High mortality in ovarian cancer patients is primarily caused through rapid metastasis of the
tumour, but the underlying mechanisms are poorly understood. Glycosaminoglycans, are …

Glycosaminoglycans are long polysaccharidic chains, which are mostly present in
connective tissues. Modified GAG expression in tissues surrounding malignant cells has …

The remarkable structural heterogeneity of chondroitin sulfate (CS) and dermatan sulfate
(DS) generates biological information that can be unique to each of these …