Shikonin is an anthraquinone derivative extracted from the root of lithospermum. Shikonin is
traditionally used in the treatment of inflammatory and infectious diseases such as hepatitis …

Ethnopharmacological relevance Shikonin, one of the main active ingredients of Chinese
herbal medicine Lithospermum erythrorhizon, has been widely used to treat various disease …

Though previous study demonstrated that shikonin could exert its antitumor activity by
inducing apoptosis and necrosis, the pro-survival mechanisms involved in its antitumor …

High invasiveness is a biological and clinical characteristic of glioblastoma and predicts
poor prognosis of patients. Quercetin, a natural flavonoid compound, exhibits anticancer …

Background: Glioblastoma multiforme (GBM) is the most aggressive and malignant primary
brain tumor characterized by rapid growth and extensive infiltration to neighboring normal …

Shikonin, a traditional Chinese medicine, has been identified as being capable of inducing
apoptosis in various tumors, including glioma, and is thus considered to be a promising …

Eriodictyol (ERD) is a natural flavonoid that exists in many vegetables and fruits, especially
citrus fruits. It has been proven to have many pharmacological effects, such as antioxidative …

Echinacoside is a group of natural compounds extracted from medicinal plants Cistanche
and Echinacea, which has neuroprotective, antiaging, immunomodulatory and anticancer …

Baicalein, one of the major flavonids in Scutellaria baicalensis, has historically been used in
anti-inflammatory and anti-cancer therapies. However, the anti-metastatic effect and related …

Plumbagin is a natural naphthoquinone constituent isolated from the roots of medicinal plant
Plumbago zeylanica L., and has demonstrated anti-proliferative and anti-invasion activities …