Critical role of lipid composition in membrane permeabilization by rabbit neutrophil defensins
We have examined the interactions of the six known rabbit neutrophil defensin antimicrobial
peptides with large unilamellar vesicles (LUV) made from various lipid mixtures based on …
peptides with large unilamellar vesicles (LUV) made from various lipid mixtures based on …
Interactions between human defensins and lipid bilayers: evidence for formation of multimeric pores
Defensins comprise a family of broad‐spectrum antimicrobial peptides that are stored in the
cytoplasmic granules of mammalian neutrophils and Paneth cells of the small intestine …
cytoplasmic granules of mammalian neutrophils and Paneth cells of the small intestine …
Interactions of monomeric rabbit neutrophil defensins with bilayers: comparison with dimeric human defensin HNP-2
Human antimicrobial neutrophil defensin HNP-2 has been shown to form large multimeric
pores in pure 1-palmitoyl-2-oleoyl phosphatidylglycerol (POPG) bilayers that lead to all-or …
pores in pure 1-palmitoyl-2-oleoyl phosphatidylglycerol (POPG) bilayers that lead to all-or …
[HTML][HTML] Functional interaction of human neutrophil peptide-1 with the cell wall precursor lipid II
E de Leeuw, C Li, P Zeng, C Li, M Diepeveen-de Buin… - FEBS letters, 2010 - Elsevier
Defensins constitute a major class of cationic antimicrobial peptides in mammals and
vertebrates, acting as effectors of innate immunity against infectious microorganisms. It is …
vertebrates, acting as effectors of innate immunity against infectious microorganisms. It is …
Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes.
Defensins are cationic, cysteine-rich peptides (Mr= 3500-4000) found in the cytoplasmic
granules of neutrophils and macrophages. These peptides possess broad antimicrobial …
granules of neutrophils and macrophages. These peptides possess broad antimicrobial …
Effect of small cationic leukocyte peptides (defensins) on the permeability barrier of the outer membrane
P Viljanen, P Koski, M Vaara - Infection and immunity, 1988 - Am Soc Microbiol
Defensins are small cationic antibacterial peptides that are abundant in polymorphonuclear
leukocytes from human and other sources (T. Ganz, M. Selsted, D. Szklarek, S. Harwig, K …
leukocytes from human and other sources (T. Ganz, M. Selsted, D. Szklarek, S. Harwig, K …
Cationic defensins arise from charge‐neutralized propeptides: a mechanism for avoiding leukocyte autocytotoxicity?
D Michaelson, J Rayner, M Couto… - Journal of leukocyte …, 1992 - Wiley Online Library
Defensins, small cationic polypeptides with antimicrobial and cytotoxic properties, are
among the principal constituents of cytoplasmic granules of mammalian neutrophils and …
among the principal constituents of cytoplasmic granules of mammalian neutrophils and …
Differential Scanning Microcalorimetry Indicates That Human Defensin, HNP-2, Interacts Specifically with Biomembrane Mimetic Systems,
α-Defensins are antimicrobial peptides with 29− 35 amino acid residues and cysteine-
stabilized amphiphilic, triple-stranded β-sheet structures. We used high-precision differential …
stabilized amphiphilic, triple-stranded β-sheet structures. We used high-precision differential …
Defensins in granules of phagocytic and non-phagocytic cells
ME Selsted, AJ Ouellette - Trends in cell biology, 1995 - cell.com
Antimicrobial proteins stored in lysosome-like granules of neutrophils and macrophages
probably play an important role in killing phagocytosed microbes after delivery to the …
probably play an important role in killing phagocytosed microbes after delivery to the …
Mechanism of mammalian cell lysis mediated by peptide defensins. Evidence for an initial alteration of the plasma membrane.
A Lichtenstein - The Journal of clinical investigation, 1991 - Am Soc Clin Investig
Defensins induce ion channels in model lipid bilayers and permeabilize the membranes of
Escherichia coli. We investigated whether similar membrane-active events occur during …
Escherichia coli. We investigated whether similar membrane-active events occur during …