Immunopathogenesis of HTLV-I-associated myelopathy/tropical spastic paraparesis

T Nakamura - Annals of medicine, 2000 - Taylor & Francis
The main pathological feature of human T-lymphotropic virus type I (HTLV-1)-associated
myelopathy/tropical spastic paraparesis (HAWTSP) is chronic inflammation of the spinal …

Pathogenesis of human T‐lymphotropic virus type 1‐associated myelopathy/tropical spastic paraparesis

R Kubota - Clinical and Experimental Neuroimmunology, 2017 - Wiley Online Library
Human T‐lymphotropic virus type 1 (HTLV‐1) is a human retrovirus that preferentially infects
CD 4+ lymphocytes in vivo. The virus causes a hematological malignancy known as adult T …

Virological aspects of tropical spastic paraparesis/HTLV-I associated myelopathy and HTLV-I infection

A Gessain - Journal of neurovirology, 1996 - Taylor & Francis
TSP/HAM, a chronic spastic paraparesis or paraplegia with sphincter disturbances and
minimal sensory loss, is characterized pathologically by a meningo-myelitis of the lower …

HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP): the role of HTLV-I-infected Th1 cells in the pathogenesis, and therapeutic strategy

T Nakamura - Folia Neuropathologica, 2009 - termedia.pl
FOLIA 2-2009 Page 1 Folia Neuropathologica 2009; 47/2 182 HTLV-I-associated
myelopathy/tropical spastic paraparesis (HAM/TSP): the role of HTLV-I-infected Th1 cells in the …

Perivascular T cells are infected with HTLV-I in the spinal cord lesions with HTLV-I-associated myelopathy/tropical spastic paraparesis: double staining of …

E Matsuoka, N Takenouchi, K Hashimoto, N Kashio… - Acta …, 1998 - Springer
HTLV-I-infected cells play an important role in pathogenesis HTLV-I-associated
myelopathy/tropical spastic paraparesis (HAM/TSP). Our previous studies of quantitative …

Human T lymphotropic virus type I (HTLV-I) proviral load in cerebrospinal fluid: a new criterion for the diagnosis of HTLV-I–associated myelopathy/tropical spastic …

A Lezin, S Olindo, S Oliere… - The Journal of …, 2005 - academic.oup.com
Human T lymphotropic virus type I (HTLV-I)–associated myelopathy/tropical spastic
paraparesis (HAM/TSP) is associated with accumulation of HTLV-I–infected T cells in the …

In vitro virus propagation and high cellular responsiveness to the infected cells in patients with HTLV-I-associated myelopathy (HAM/TSP)

K Machigashira, S Ijichi, M Nagai, Y Yamano… - Journal of the …, 1997 - Elsevier
The reasons for the development of HTLV-I-associated myelopathy/tropical spastic
paraparesis (HAM/TSP) in certain infected individuals remain poorly understood, but the …

HTLV-I proviral load correlates with progression of motor disability in HAM/TSP: analysis of 239 HAM/TSP patients including 64 patients followed up for 10 years

T Matsuzaki, M Nakagawa, M Nagai, K Usuku… - Journal of …, 2001 - Springer
To clarify clinical and laboratory findings that may be related to the pathomechanism of
HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), we analyzed these …

Demonstration of human T lymphotropic virus type I (HTLV-I) tax-specific CD8+ lymphocytes directly in peripheral blood of HTLV-I-associated myelopathy/tropical …

R Kubota, T Kawanishi, H Matsubara… - The Journal of …, 1998 - journals.aai.org
Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic
paraparesis (HAM/TSP) is an inflammatory neurologic disease caused by HTLV-I infection …

Cell surface phenotype of in vitro proliferating lymphocytes in HTLV-I-associated myelopathy (HAM/TSP)

N Eiraku, S Ijichi, S Yashiki, M Osame… - Journal of …, 1992 - Elsevier
The in vitro proliferation of peripheral blood lymphocytes (PBLs) without any mitogenic
stimulation is one of the hallmarks of human T lymphotropic virus type I (HTLV-I) infection …