Correlation between the proportion of Philadelphia chromosome‐positive metaphase cells and levels of BCR‐ABL mRNA in chronic myeloid leukaemia
F Lin, A Chase, J Bungey, JM Goldman… - Genes …, 1995 - Wiley Online Library
We have sought to define the relationship between the proportion of marrow metaphases
showing the Philadelphia chromosome (Ph) and levels of BCR‐ABL mRNA assessed by …
showing the Philadelphia chromosome (Ph) and levels of BCR‐ABL mRNA assessed by …
Transcription-mediated amplification and hybridisation protection assay to determine BCR-ABL transcript levels in patients with chronic myeloid leukaemia
SE Langabeer, RE Gale, RC Harvey, RW Cook… - Leukemia, 2002 - nature.com
Detection of BCR-ABL transcripts in chronic myeloid leukaemia (CML) is used to confirm the
diagnosis and to monitor residual disease. Quantitative techniques are required to predict …
diagnosis and to monitor residual disease. Quantitative techniques are required to predict …
Comparative study of BCR-ABL1 quantification: Xpert assay, a feasible solution to standardization concerns
CE López-Jorge, MT Gómez-Casares… - Annals of …, 2012 - Springer
The level of BCR-ABL1 reached after treatment with tyrosine kinase inhibitors is an effective
marker of the therapeutic response and a good survival predictor in chronic myeloid …
marker of the therapeutic response and a good survival predictor in chronic myeloid …
Detection by enzymatic amplification of bcr-abl mRNA in peripheral blood and bone marrow cells of patients with chronic myelogenous leukemia
W Lange, DS Snyder, R Castro, JJ Rossi, KG Blume - 1989 - ashpublications.org
The Philadelphia chromosome of chronic myelogenous leukemia (CML) patients is caused
by a translocation of the c-abl gene from chromosome 9 to the breakpoint cluster region (bcr) …
by a translocation of the c-abl gene from chromosome 9 to the breakpoint cluster region (bcr) …
Comprehensive validation of a real-time quantitative bcr-abl assay for clinical laboratory use
CD Jones, C Yeung, JL Zehnder - American journal of clinical …, 2003 - academic.oup.com
We developed and extensively validated a real-time PCR assay for the quantitation of bcr-
abl to determine residual disease in patients with chronic myelogenous leukemia. This …
abl to determine residual disease in patients with chronic myelogenous leukemia. This …
Harmonization of BCR-ABL mRNA quantification using a uniform multifunctional control plasmid in 37 international laboratories
Individualized PCR strategies hamper comparability of molecular results between different
laboratories in several fields of medicine. To harmonize BCR-ABL mRNA quantification an …
laboratories in several fields of medicine. To harmonize BCR-ABL mRNA quantification an …
Molecular measurement of BCR-ABL transcript variations in chronic myeloid leukemia patients in cytogenetic remission
M Serpa, SS Sanabani, PE Dorliac-Llacer, M Conchon… - BMC Hematology, 2010 - Springer
Background The monitoring of BCR-ABL transcript levels by real-time quantitative
polymerase chain reaction (RT-qPCR) has become important to assess minimal residual …
polymerase chain reaction (RT-qPCR) has become important to assess minimal residual …
Comparison of competitive-nested PCR and real-time PCR in detecting BCR-ABL fusion transcripts in chronic myeloid leukemia patients
JQ Guo, H Lin, H Kantarjian, M Talpaz, R Champlin… - Leukemia, 2002 - nature.com
Real-time RT-PCR has great advantages for estimating transcript levels in a variety of
situations. These include relative rapid assay times (hours), reliability and ease of …
situations. These include relative rapid assay times (hours), reliability and ease of …
BCR-ABL expression in different subpopulations of functionally characterized Ph+ CD34+ cells from patients with chronic myeloid leukemia
V Maguer-Satta, AL Petzer, AC Eaves, CJ Eaves - 1996 - ashpublications.org
In patients with chronic myeloid leukemia (CML), the leukemic (BCR-ABL+/Ph+) clone
typically includes cells belonging to all of the myeloid lineages and frequently some B cells …
typically includes cells belonging to all of the myeloid lineages and frequently some B cells …
Comparison of bcr-abl Protein Expression and Philadelphia Chromosome Analyses in Chronic Myelogenous Leukemia Patients
JQ Guo, J Lian, A Glassman, M Talpaz… - American journal of …, 1996 - academic.oup.com
Abstract The Philadelphia chromosome (Ph) is found in most chronic myelogenous
leukemia (CML) patients. The bcr-abl oncoprotein (P210 or PI85), the product of the fused …
leukemia (CML) patients. The bcr-abl oncoprotein (P210 or PI85), the product of the fused …