Synthesis and preliminary structure-activity relationship study of 3-methylquinazolinone derivatives as EGFR inhibitors with enhanced antiproliferative activities …
Y Zhang, Q Wang, L Li, Y Le, L Liu, J Yang… - Journal of Enzyme …, 2021 - Taylor & Francis
In this paper, a set of 3-methylquniazolinone derivatives were designed, synthesised, and
studied the preliminary structure-activity relationship for antiproliferative activities. All target …
studied the preliminary structure-activity relationship for antiproliferative activities. All target …
Design, synthesis and in vitro biological evaluation of quinazolinone derivatives as EGFR inhibitors for antitumor treatment
Y Le, Y Gan, Y Fu, J Liu, W Li, X Zou… - Journal of enzyme …, 2020 - Taylor & Francis
In this paper, a series of novel 3-methyl-quinazolinone derivatives was designed,
synthesised and evaluated for antitumor activity in vitro on wild type epidermal growth factor …
synthesised and evaluated for antitumor activity in vitro on wild type epidermal growth factor …
Design, Synthesis and Molecular Docking of Novel Quinazolinone Hydrazide Derivatives as EGFR Inhibitors
ZY Fang, YH Zhang, CH Chen, Q Zheng… - Chemistry & …, 2022 - Wiley Online Library
A series of novel quinazolinone hydrazide derivatives were designed and synthesized as
EGFR inhibitors. The results indicated that most of the aimed compounds had potential anti …
EGFR inhibitors. The results indicated that most of the aimed compounds had potential anti …
Design and synthesis of novel quinazolinone-based derivatives as EGFR inhibitors with antitumor activity
Abstract Nineteen new quinazolin-4 (3 H)-one derivatives 3a–g and 6a–l were designed
and synthesised to inhibit EGFR. The antiproliferative activity of the synthesised compounds …
and synthesised to inhibit EGFR. The antiproliferative activity of the synthesised compounds …
Novel 4-arylaminoquinazoline derivatives with (E)-propen-1-yl moiety as potent EGFR inhibitors with enhanced antiproliferative activities against tumor cells
L Chen, Y Zhang, J Liu, W Wang, X Li, L Zhao… - European Journal of …, 2017 - Elsevier
A series of novel 4-anilinoquinazoline derivatives with (E)-propen-1-yl moiety were
designed, synthesized and evaluated for biological activities in vitro. Most compounds …
designed, synthesized and evaluated for biological activities in vitro. Most compounds …
Design, synthesis and in vitro anti-proliferative activity of 4, 6-quinazolinediamines as potent EGFR-TK inhibitors
4-Anilino-6-substituted-quinazolines were designed, synthesized and evaluated for EGFR-
TK and tumor growth inhibitory activities. The target compounds were designed with …
TK and tumor growth inhibitory activities. The target compounds were designed with …
Synthesis, in vitro antitumour activity, and molecular docking study of novel 2-substituted mercapto-3-(3,4,5-trimethoxybenzyl)-4(3H)-quinazolinone analogues
AS El-Azab, AAM Abdel-Aziz… - Journal of Enzyme …, 2017 - Taylor & Francis
A novel series of 2-substituted mercapto-3-(3, 4, 5-trimethoxybenzyl)-4 (3H)-quinazolinones
1–20 was synthesised and evaluated for in vitro antitumour activity. N-(4-Chlorophenyl)-2-[(3 …
1–20 was synthesised and evaluated for in vitro antitumour activity. N-(4-Chlorophenyl)-2-[(3 …
Design, synthesis and assessment of new series of quinazolinone derivatives as EGFR inhibitors along with their cytotoxic evaluation against MCF7 and A549 cancer …
New acetamide (IV ae) and 1, 3-thiazolidinone derivatives (VII ae) were designed,
synthesized and assessed for their cytotoxic activity against MCF-7 and A549 cell lines …
synthesized and assessed for their cytotoxic activity against MCF-7 and A549 cell lines …
Novel 4-arylaminoquinazolines bearing N,N-diethyl(aminoethyl)amino moiety with antitumour activity as EGFRwt-TK inhibitor
Y Zhang, L Chen, X Li, L Gao, Y Hao… - Journal of Enzyme …, 2019 - Taylor & Francis
Herein, four novel 4-arylaminoquinazoline derivatives with N, N-diethyl (aminoethyl) amino
moiety were designed, synthesised and evaluated on biological activities in vitro. All …
moiety were designed, synthesised and evaluated on biological activities in vitro. All …
Facile and efficient synthesis and biological evaluation of 4-anilinoquinazoline derivatives as EGFR inhibitors
Z Wang, X Wu, L Wang, J Zhang, J Liu, Z Song… - Bioorganic & Medicinal …, 2016 - Elsevier
Abstract Series of 4-anilinoquinazoline derivatives were conveniently and efficiently
synthesized and their antitumor activities were evaluated by MTT assay in three human …
synthesized and their antitumor activities were evaluated by MTT assay in three human …