DNA mismatch repair (MMR) is an important DNA repair pathway that plays critical roles in
DNA replication fidelity, mutation avoidance and genome stability, all of which contribute …

Ensuring high-fidelity DNA replication is essential for maintaining genome stability in
organisms from Escherichia coli to humans. This task requires an intricate network of cellular …

Using electron microscopy and indirect end-labeling methods, we have examined excision
tracts produced by the Escherichia coli methyl-directed mismatch repair system on a closed …

The mismatch repair proteins, MutS and MutL, interact in a DNA mismatch and ATP-
dependent manner to activate downstream events in repair. Here, we assess the role of ATP …

Mismatch repair (MMR) proteins contribute to genome stability by excising DNA mismatches
introduced by DNA polymerase. Although MMR proteins are also known to influence cellular …

DNA mismatch repair (MMR) is a conserved pathway that safeguards genome integrity by
correcting replication errors. The coordinated actions of two proteins (MutS and MutL) initiate …

In eukaryotes the MSH2-MSH3 and MSH2-MSH6 heterodimers initiate mismatch repair
(MMR) by recognizing and binding to DNA mismatches. The MLH1-PMS1 heterodimer then …

The mismatch repair (MMR) system promotes genomic fidelity by repairing base-base
mismatches, insertion-deletion loops and heterologies generated during DNA replication …

Methyl-directed mismatch repair is a coordinated process that ensures replication fidelity
and genome integrity by resolving base pair mismatches and insertion/deletion loops. This …

I first learned about the existence of DNA mismatch repair (MMR) in the early 1970's as a
graduate student from Robert “Bob” C. Warner, who was one of the few people in our …