Bronchodilating drugs for chronic obstructive pulmonary disease: current status and future trends

P Montuschi, G Ciabattoni - Journal of medicinal chemistry, 2015 - ACS Publications
Inhaled bronchodilators, including long-acting muscarinic receptor antagonists (LAMA) and
long-acting β2-adrenoreceptor agonists (LABA), are the mainstay of pharmacological …

Differential pharmacology and clinical utility of emerging combination treatments in the management of COPD–role of umeclidinium/vilanterol

M Malerba, JB Morjaria, A Radaeli - International journal of chronic …, 2014 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease
characterized by airflow limitation that is not fully reversible. Bronchodilator therapy is the …

Pharmacology and therapeutics of bronchodilators

M Cazzola, CP Page, L Calzetta, MG Matera - Pharmacological Reviews, 2012 - ASPET
Bronchodilators are central in the treatment of of airways disorders. They are the mainstay of
the current management of chronic obstructive pulmonary disease (COPD) and are critical in …

New combination bronchodilators for chronic obstructive pulmonary disease: current evidence and future perspectives

D Singh - British Journal of Clinical Pharmacology, 2015 - Wiley Online Library
Fixed dose combination (FDC) dual bronchodilators that co‐administer a long acting β2‐
adrenoceptor agonist (LABA) and a long acting muscarinic antagonist (LAMA) are a new …

[HTML][HTML] Role of dual bronchodilators in COPD: a review of the current evidence for indacaterol/glycopyrronium

JH Ficker, KF Rabe, T Welte - Pulmonary pharmacology & therapeutics, 2017 - Elsevier
In this review, we summarize the rationale for combining long-acting bronchodilators in the
management of chronic obstructive pulmonary disease (COPD), and the evidence for the …

Ultra long-acting β-agonists in chronic obstructive pulmonary disease

RM Burkes, RJ Panos - Journal of Experimental Pharmacology, 2020 - Taylor & Francis
Introduction Inhaled β-agonists have been foundational medications for maintenance COPD
management for decades. Through activation of cyclic adenosine monophosphate …

Long-acting bronchodilators for chronic obstructive pulmonary disease: which one (s), how, and when?

AG Mathioudakis, J Vestbo… - Clinics in Chest …, 2020 - chestmed.theclinics.com
Chronic obstructive pulmonary disease (COPD) is characterized by chronic respiratory
symptoms, such as breathlessness and chronic productive cough, limited exercise …

Fixed-dose combinations of long-acting bronchodilators for the management of COPD: global and asian perspectives

CK Rhee, H Yoshisue, R Lad - Advances in Therapy, 2019 - Springer
Maintenance bronchodilator therapy with long-acting β-agonists (LABAs) and long-acting
muscarinic antagonists (LAMAs) is the cornerstone treatment for patients with stable chronic …

An update on bronchodilators in Phase I and II clinical trials

M Cazzola, P Rogliani, A Segreti… - Expert opinion on …, 2012 - Taylor & Francis
Introduction: Inhaled bronchodilators are the mainstay of the current management of COPD
at all stages of the disease, and are critical in the symptomatic management of asthma …

Considerations for new dual-acting bronchodilator treatments for chronic obstructive pulmonary disease

J de Miguel-Díez, R Jiménez-García - Expert Opinion on …, 2014 - Taylor & Francis
Current guidelines recommend treatment with one or more bronchodilators for chronic
obstructive pulmonary disease (COPD) patients. Combination therapy with long-acting …