Retinoblastoma tumor suppressor protein (pRb) regulates various biological processes
during development and tumorigenesis. Although the molecular mechanism by which pRb …

The retinoblastoma gene Rb is the prototype tumor suppressor and is conserved in
Drosophila. We use the developing fly retina as a model system to investigate the role of …

Retinoblastoma (RB) tumor suppressor proteins are important regulators of the cell cycle
and are implicated in a wide variety of human tumors. Genetic analysis of RB mutations in …

The RB tumor suppressor, a regulator of the cell cycle, apoptosis, senescence, and
differentiation, is frequently mutated in human cancers. We recently described an …

Retinoblastoma proteins are eukaryotic transcriptional corepressors that play central roles in
cell cycle control, among other functions. Although most metazoan genomes encode a …

The retinoblastoma gene Rb is a prototype tumor suppressor which is conserved in
Drosophila. Although much is known about the roles of Rb in cell proliferation and …

The retinoblastoma (RB) tumor suppressor family functions as a regulatory node governing
cell cycle progression, differentiation, and apoptosis. Post-translational modifications play a …

Inactivation of the retinoblastoma gene Rb leads to defects in cell proliferation,
differentiation, or apoptosis, depending on specific cell or tissue types. To gain insights into …

The function of Retinoblastoma tumor suppressor (pRB) is greatly influenced by the cellular
context, therefore the consequences of pRB inactivation are cell-type-specific. Here we …

The variety of human cancers in which the retinoblastoma protein pRb is inactivated reflects
both its broad importance for tumor suppression and its multitude of cellular functions …