Abstract Aims Endothelial cells (ECs) control vascular permeability by forming a monolayer
that is sealed by extracellular junctions. Various mediators modulate the endothelial barrier …

RhoGTPases are known regulators of intracellular actin dynamics that are important for
maintaining endothelial barrier function. RhoA is most extensively studied as a key regulator …

In the past decade understanding of the role of the Rho GTPases RhoA, Rac1 and Cdc42
has been developed from regulatory proteins that regulate specific actin cytoskeletal …

Although the endothelium is an extremely thin single-cell layer, it performs exceedingly well
in preventing blood fluids from leaking into the surrounding tissues. However, specific …

ABSTRACT VE-cadherin-based cell-cell junctions form the major restrictive barrier of the
endothelium to plasma proteins and blood cells. The function of VE-cadherin and the actin …

In the present study, the roles of the small GTPase RhoA and its target Rho kinase in
endothelial permeability were investigated in vitro. We have shown previously that, in …

Objective—Rho kinase mediates vascular leakage caused by many vasoactive agents
including thrombin. Enhanced Rho kinase activity induces endothelial barrier dysfunction by …

Endothelial permeability depends on the integrity of intercellular junctions as well as
actomyosin-based cell contractility. Rho GTPases have been implicated in signalling by …

Within blood vessels, endothelial cell–cell and cell–matrix adhesions are crucial to preserve
barrier function, and these adhesions are tightly controlled during vascular development …

From studies using macrovascular endothelium, it was concluded that Rho A activation
generally leads to endothelial barrier breakdown. Here, we characterized the role of Rho …