Notch2-dependent DC2s mediate splenic germinal center responses

CG Briseño, AT Satpathy… - Proceedings of the …, 2018 - National Acad Sciences
CD4+ T follicular helper (TFH) cells support germinal center (GC) reactions promoting
humoral immunity. Dendritic cell (DC) diversification into genetically distinct subsets allows …

[HTML][HTML] Human lymphoid organ cDC2 and macrophages play complementary roles in T follicular helper responses

M Durand, T Walter, T Pirnay, T Naessens… - Journal of Experimental …, 2019 - rupress.org
CD4+ T follicular helper (Tfh) cells are essential for inducing efficient humoral responses. T
helper polarization is classically orientated by dendritic cells (DCs), which are composed of …

Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation

A Garin, M Meyer-Hermann, M Contie, MT Figge… - Immunity, 2010 - cell.com
Germinal centers (GCs) are specialized microenvironments where antigen-activated B cells
undergo proliferation, immunoglobulin (Ig) class switch recombination, somatic …

Complementary diversification of dendritic cells and innate lymphoid cells

CG Briseño, TL Murphy, KM Murphy - Current opinion in immunology, 2014 - Elsevier
Highlights•Transcriptional requirements of DC subset development.•Batf3-dependent
CD8α+ DCs mediate type I immune responses.•CD11b+ DCs orchestrate ILC3 and TH 17 …

Broad and largely concordant molecular changes characterize tolerogenic and immunogenic dendritic cell maturation in thymus and periphery

L Ardouin, H Luche, R Chelbi, S Carpentier, A Shawket… - Immunity, 2016 - cell.com
Dendritic cells (DCs) are instrumental in the initiation of T cell responses, but how thymic
and peripheral tolerogenic DCs differ globally from Toll-like receptor (TLR)-induced …

IL-10-dependent crosstalk between murine marginal zone B cells, macrophages, and CD8α+ dendritic cells promotes Listeria monocytogenes infection

D Liu, X Yin, SJ Olyha, MSL Nascimento, P Chen… - Immunity, 2019 - cell.com
Type 1 CD8α+ conventional dendritic cells (cDC1s) are required for CD8+ T cell priming but,
paradoxically, promote splenic Listeria monocytogenes infection. Using mice with impaired …

CX3CR1+ CD8α+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells

L Bar-On, T Birnberg, KL Lewis… - Proceedings of the …, 2010 - National Acad Sciences
Lymphoid organs are characterized by a complex network of phenotypically distinct dendritic
cells (DC) with potentially unique roles in pathogen recognition and immunostimulation …

Maintenance of T cell specification and differentiation requires recurrent notch receptor–ligand interactions

TM Schmitt, M Ciofani, HT Petrie… - The Journal of …, 2004 - rupress.org
Notch signaling has been shown to play a pivotal role in inducing T lineage commitment.
However, T cell progenitors are known to retain other lineage potential long after the first …

Extrafollicular B cell activation by marginal zone dendritic cells drives T cell–dependent antibody responses

CP Chappell, KE Draves, NV Giltiay… - Journal of Experimental …, 2012 - rupress.org
Dendritic cells (DCs) are best known for their ability to activate naive T cells, and emerging
evidence suggests that distinct DC subsets induce specialized T cell responses. However …

[HTML][HTML] Development and function of dendritic cell subsets

A Mildner, S Jung - Immunity, 2014 - cell.com
Classical dendritic cells (cDCs) form a critical interface between innate and adaptive
immunity. As myeloid immune cell sentinels, cDCs are specialized in the sensing of …