Human malignant tumors are characterized by pervasive changes in the patterns of DNA
methylation. These changes include a globally hypomethylated tumor cell genome and the …

Recently, the concept that epigenetic, as well as genetic, events might be central to the
evolution of human cancer is re-emerging. Cancers often exhibit an aberrant methylation of …

Cytosine methylation is a heritable modification of DNA in mammalian cells, and has a
determinant impact on long-term gene repression and genome stability. Genomic …

The spatial arrangement and three-dimensional structure of DNA in the nucleus is controlled
through the interdigitation of DNA binding proteins such as histones and their modifiers, the …

There is compelling evidence to support the importance of DNA methylation alterations in
cancer development. Both losses and gains of DNA methylation are observed, thought to …

The epigenome, which is comprised of chromatin and its associated proteins and the
patterns of covalent modification of DNA by methylation, sets up and maintains gene …

Epigenetic alterations such as DNA methylation have been implicated in the development
and progression of various cancers. DNA methylation consists of the reversible addition of a …

DNA methylation is a chemical modification that defines cell type and lineage through the
control of gene expression and genome stability. Disruption of DNA methylation control …

DNA methylation regulates many cellular processes, including embryonic development,
transcription, chromatin structure, X-chromosome inactivation, genomic imprinting and …

In contrast to earlier views that there was much compartmentalization of the types of
sequences subject to cancer-linked changes in DNA epigenetics, it is now clear that both …