Aziridine alkaloids as potential therapeutic agents

FMD Ismail, DO Levitsky, VM Dembitsky - European journal of medicinal …, 2009 - Elsevier
The present review describes research on natural aziridine alkaloids isolated from both
terrestrial and marine species, as well as their lipophilic semi-synthetic, and/or synthetic …

Synthesis and Reactivity of C-Heteroatom-Substituted Aziridines

GS Singh, M D'hooghe, N De Kimpe - Chemical reviews, 2007 - ACS Publications
The smallest possible saturated azaheterocycle, aziridine, is well-known to organic chemists
for its tremendous potential in organic synthesis and medicinal chemistry. 1 Even though …

Synthetic aziridines in medicinal chemistry: a mini-review

GS Singh - Mini reviews in medicinal chemistry, 2016 - ingentaconnect.com
Azaheterocyclic compounds are well-known to have diverse types of biological activity.
Among them, azacyclopropanes, commonly referred as aziridines, occupy a prominent …

Recent advances in the accessibility, synthetic utility, and biological applications of aziridines

C Dank, L Ielo - Organic & Biomolecular Chemistry, 2023 - pubs.rsc.org
Compounds featuring aziridine moieties are widely known and extensively reported in the
literature. Due to their great potential from both synthetic and pharmacological points of …

Aziridinyl anions: Generation, reactivity, and use in modern synthetic chemistry

S Florio, R Luisi - Chemical reviews, 2010 - ACS Publications
Aziridines, nitrogen-containing three-membered ring heterocycles, are well established
useful and versatile building blocks in organic synthesis and medicinal chemistry. 1 …

Recent advances in 2H-azirine chemistry

AF Khlebnikov, MS Novikov - Tetrahedron, 2013 - Elsevier
2H-Azirines, compounds with a three-membered ring, consisting of two carbon atoms and
one nitrogen atom with a C double bond N double bond, are the most strained nitrogen …

Synthesis and applications of vinylaziridines and ethynylaziridines

H Ohno - Chemical Reviews, 2014 - ACS Publications
Among the variously functionalized aziridines, 1 vinylaziridines and ethynylaziridines are
increasingly being exploited as versatile building blocks in organic synthesis. Compounds of …

Recent advances in the stereoselective synthesis of aziridines

L Degennaro, P Trinchera, R Luisi - Chemical Reviews, 2014 - ACS Publications
Aziridines, the smallest nitrogen-containing heterocycles, are useful building blocks in
synthesis, as well as important synthetic targets (Scheme 1). 1 The interest toward synthetic …

PREPARATION, PROPERTIES AND SYNTHETIC APPLICATIONS OF 2H-AZIRINES A REVIEW

F Palacios, AMO de Retana… - Organic Preparations …, 2002 - Taylor & Francis
Azirine is the term used to describe the smallest nitrogen unsaturated heterocyclic system,
containing two carbon atoms and one double bond in a three-membered ring. Interest in …

Recent developments in asymmetric aziridination

H Pellissier - Tetrahedron, 2010 - Elsevier
Aziridines are saturated three-membered heterocycles containing one nitrogen atom. These
compounds are among the most fascinating intermediates in organic synthesis, acting as …