The major histocompatibility complex class I-restricted cytotoxic T lymphocyte (CTL)
response is important in the clearance of viral infections in humans. After influenza A …

Eight HLA B7‐restricted influenza A virus nucleoprotein 383–391‐specific cytotoxic T
lymphocyte (CTL) clones were obtained from three unrelated donors following natural …

Previous studies have indicated that in transgenic mice expressing human class I MHC
molecules, it is difficult to demonstrate a significant CTL response to a viral Ag in the context …

Previous results from this laboratory demonstrated that the dominant influenza A epitope
recognized by HLA-A2. 1-restricted cytotoxic T lymphocytes (CTL) from HLA-A2. 1 …

Transgenic murine lines have been constructed that express a chimeric class I molecule
composed of the alpha 1 and alpha 2 domains of HLA-A2. 1 and the alpha 3 …

The major histocompatibility complex class I molecule HLA-A2. 1 presents the influenza A
virus matrix peptide 57-68 to cytotoxic T lymphocytes in all individuals with this common HLA …

The memory T cell response is polyclonal, with the magnitude and specificity of the
response controlled in part by the burst size of T cells expanded from effector/memory …

Viruses can exploit a variety of strategies to evade immune surveillance by cytotoxic T
lymphocytes (CTL), including the acquisition of mutations in or adjacent to CTL epitopes …

In the present study, the recognition of epitope variants of influenza A viruses by human CTL
was investigated. To this end, human CD8+ CTL clones, specific for natural variants of the …

The requirement for specific T cell subsets in the in vitro generation of human influenza virus-
immune cytotoxic T lymphocyte (CTL) responses was investigated. Peripheral blood T cell …