In VivoLongitudinal Analysis of a Dominant TCR Repertoire Selected in Human Response to Influenza Virus
A Prevost-Blondel, R Lengagne, F Letourneur… - Virology, 1997 - Elsevier
Recent studies have demonstrated biased usage of TCR Vβ17 and a high degree of
diversity in Jβ usage within the influenza virus matrix epitope (M. 58-66)-specific CTL …
diversity in Jβ usage within the influenza virus matrix epitope (M. 58-66)-specific CTL …
In vivo selection of a TCR Vβ repertoire directed against an immunodominant influenza virus CTL epitope
W Zhong, EL Reinherz - International immunology, 2004 - academic.oup.com
Little is known about the mechanisms governing TCR repertoire selection in response to
foreign antigens. Here, we evaluate the molecular features of the murine C57BL/6 (B6) TCR …
foreign antigens. Here, we evaluate the molecular features of the murine C57BL/6 (B6) TCR …
Influenza A antigen exposure selects dominant Vβ17+ TCR in human CD8+ cytotoxic T cell responses
TM Lawson, S Man, S Williams… - International …, 2001 - academic.oup.com
During acute human viral infections, such as influenza A, specific cytotoxic T lymphocytes
(CTL) are generated which aid virus clearance. We have observed that in HLA-A* 0201+ …
(CTL) are generated which aid virus clearance. We have observed that in HLA-A* 0201+ …
Conserved T cell receptor usage in primary and recall responses to an immunodominant influenza virus nucleoprotein epitope
K Kedzierska, SJ Turner… - Proceedings of the …, 2004 - National Acad Sciences
The CD8+ T cell response to the immunodominant DbNP366 epitope has been analyzed
sequentially to determine the prevalence and persistence of different T cell antigen receptor …
sequentially to determine the prevalence and persistence of different T cell antigen receptor …
Homogenization of TCR repertoires within secondary CD62Lhigh and CD62Llow virus-specific CD8+ T cell populations
K Kedzierska, V Venturi, SA Valkenburg… - The Journal of …, 2008 - journals.aai.org
Influenza virus-specific CD8+ T cell clonotypes generated and maintained in C57BL/6J mice
after respiratory challenge were found previously to distribute unequally between the CD62L …
after respiratory challenge were found previously to distribute unequally between the CD62L …
Functional differences between influenza A-specific cytotoxic T lymphocyte clones expressing dominant and subdominant TCR
TM Lawson, S Man, ECY Wang… - International …, 2001 - academic.oup.com
We have shown that the dominance of CD8+ T cells expressing TCR Vβ17 in the adult HLA-
A* 0201-restricted influenza A/M158–66-specific response is acquired following first antigen …
A* 0201-restricted influenza A/M158–66-specific response is acquired following first antigen …
Quantification of repertoire diversity of influenza-specific epitopes with predominant public or private TCR usage
K Kedzierska, EB Day, J Pi, SB Heard… - The Journal of …, 2006 - journals.aai.org
The H-2D b-restricted CD8 T cell immune response to influenza A is directed at two well-
described epitopes, nucleoprotein 366 (NP366) and acid polymerase 224 (PA224). The …
described epitopes, nucleoprotein 366 (NP366) and acid polymerase 224 (PA224). The …
Paired TCRαβ analysis of virus‐specific CD8+ T cells exposes diversity in a previously defined 'narrow' repertoire
T Cukalac, WT Kan, P Dash, J Guan… - Immunology and cell …, 2015 - Wiley Online Library
T‐cell receptor (TCR) usage has an important role in determining the outcome of CD8+
cytotoxic T‐lymphocyte responses to viruses and other pathogens. However, the …
cytotoxic T‐lymphocyte responses to viruses and other pathogens. However, the …
Fixed Expression of Single Influenza Virus–Specific TCR Chains Demonstrates the Capacity for TCR α–and β–Chain Diversity in the Face of Peptide–MHC Class I …
EB Clemens, PC Doherty, NL La Gruta… - The Journal of …, 2015 - journals.aai.org
The characteristics of the TCR repertoire expressed by epitope-specific CD8+ T cells can be
an important determinant of the quality of immune protection against virus infection. Most …
an important determinant of the quality of immune protection against virus infection. Most …
Narrowed TCR diversity for immunised mice challenged with recombinant influenza A-HIV Env311–320 virus
T Cukalac, JM Moffat, V Venturi, MP Davenport… - Vaccine, 2009 - Elsevier
Understanding CD8+ T cell responses generated by live virus vectors is critical for the
rational design of next generation HIV CTL-based vaccines. We used recombinant influenza …
rational design of next generation HIV CTL-based vaccines. We used recombinant influenza …