Efficacy, safety and cardiovascular outcomes of once‐daily oral semaglutide in patients with type 2 diabetes: the PIONEER programme

TK Thethi, R Pratley, JJ Meier - Diabetes, Obesity and …, 2020 - Wiley Online Library
Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) are recommended for glycaemic
management in patients with type 2 diabetes (T2D). Oral semaglutide, the first oral GLP …

Safety and tolerability of semaglutide across the SUSTAIN and PIONEER phase IIIa clinical trial programmes

VR Aroda, U Erhan, P Jelnes, JJ Meier… - Diabetes, Obesity …, 2023 - Wiley Online Library
Aim Glucagon‐like peptide‐1 receptor agonists improve glycaemic control: some are now
available as oral and subcutaneous formulations, and some have indications for reducing …

Comparative efficacy, safety, and cardiovascular outcomes with once-weekly subcutaneous semaglutide in the treatment of type 2 diabetes: insights from the …

VR Aroda, A Ahmann, B Cariou, F Chow… - Diabetes & …, 2019 - Elsevier
In individuals with type 2 diabetes, glycaemic control and cardiovascular risk factor
management reduces the likelihood of late-stage diabetic complications. Guidelines …

A pharmacological and clinical overview of oral semaglutide for the treatment of type 2 diabetes

A Andersen, FK Knop, T Vilsbøll - Drugs, 2021 - Springer
Oral semaglutide (Rybelsus®) is a glucagon-like peptide-1 (GLP-1) receptor agonist (GLP-
1RA) with 94% homology to human GLP-1. It is the first GLP-1RA developed for oral …

Oral semaglutide for type 2 diabetes: A systematic review and meta‐analysis

I Avgerinos, T Michailidis, A Liakos… - Diabetes, Obesity …, 2020 - Wiley Online Library
Aim To assess the efficacy and safety of oral semaglutide, a novel glucagon‐like peptide‐1
receptor agonist, for patients with type 2 diabetes. Methods We searched Medline, Embase …

Real-world use of once-weekly semaglutide in patients with type 2 diabetes: pooled analysis of data from four SURE studies by baseline characteristic subgroups

JF Yale, U Bodholdt, AM Catarig, S Catrina… - BMJ Open Diabetes …, 2022 - drc.bmj.com
Introduction This post hoc pooled analysis of four real-world studies (SURE Canada,
Denmark/Sweden, Switzerland and UK) aimed to characterize the use of once-weekly (OW) …

Clinical perspectives on the use of subcutaneous and oral formulations of semaglutide

B Gallwitz, F Giorgino - Frontiers in Endocrinology, 2021 - frontiersin.org
Early and effective glycemic control can prevent or delay the complications associated with
type 2 diabetes (T2D). The benefits of glucagon-like peptide-1 receptor agonists (GLP …

[HTML][HTML] The efficacy and safety of oral semaglutide for glycaemic management in adults with type 2 diabetes compared to subcutaneous semaglutide, placebo, and …

Y Alhindi, A Avery - Contemporary clinical trials communications, 2022 - Elsevier
Aim Semaglutide is a long-acting glucagon-like peptide-1 receptor agonist (GLP-1 RA)
indicated for glycaemic management in adults with type 2 diabetes (T2D). Oral semaglutide …

Oral semaglutide: a review of the first oral glucagon-like peptide 1 receptor agonist

JD Bucheit, LG Pamulapati, N Carter… - Diabetes technology …, 2020 - liebertpub.com
Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) are highly effective at lowering
hemoglobin A1c (HbA1c) and facilitating weight loss. Four agents in the GLP-1 RA class …

Semaglutide once weekly as add-on to SGLT-2 inhibitor therapy in type 2 diabetes (SUSTAIN 9): a randomised, placebo-controlled trial

B Zinman, V Bhosekar, R Busch, I Holst… - The lancet Diabetes & …, 2019 - thelancet.com
Background Semaglutide is a once-weekly glucagon-like peptide-1 (GLP-1) analogue for
type 2 diabetes. Few clinical trials have reported on the concomitant use of GLP-1 receptor …