DNA methylation is an epigenetic modification that is generally associated with repression of
transcription initiation at CpG-island promoters. Here we argue that, on the basis of recent …

To gain insight into the function of DNA methylation at cis-regulatory regions and its impact
on gene expression, we measured methylation, RNA polymerase occupancy and histone …

Methylation of CpG dinucleotides is a reversible modification of DNA that is highly prevalent
throughout mammalian genomes. Recent advances generated genomic DNA methylation …

In mammals, DNA methylation is a crucial epigenetic modification with key functions during
development. Cellular processes that are regulated by DNA methylation comprise X …

Methylation of cytosines is the key epigenetic modification of DNA in eukaryotes and is
associated with a repressed chromatin state and inhibition of gene expression. The …

We have developed a strategy to introduce in vitro-methylated DNA into defined
chromosomal locations. Using this system, we examined the effects of methylation on …

DNA methylation, which occurs predominantly at CpG dinucleotides, is a potent epigenetic
repressor of transcription. Because DNA methylation is reversible, there is much interest in …

DNA methylation is frequently described as a'silencing'epigenetic mark, and indeed this
function of 5-methylcytosine was originally proposed in the 1970s. Now, thanks to improved …

Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …

Ever since the discovery of DNA methylation at cytosine residues, the role of this so called
fifth base has been extensively studied and debated. Until recently, the majority of DNA …