PTX3 as a paradigm for the interaction of pentraxins with the complement system

A Inforzato, A Doni, I Barajon, R Leone… - Seminars in …, 2013 - Elsevier
Pentraxins are highly conserved components of the humoral arm of innate immunity. They
include the short pentraxins C reactive protein (CRP) and serum amyloid P component …

Pentraxins in innate immunity: from C-reactive protein to the long pentraxin PTX3

A Mantovani, C Garlanda, A Doni, B Bottazzi - Journal of clinical …, 2008 - Springer
Pentraxins are a family of multimeric pattern-recognition proteins highly conserved in
evolution. Based on the primary structure of the subunit, the pentraxins are divided into two …

Pentraxins: multifunctional proteins at the interface of innate immunity and inflammation

L Deban, B Bottazzi, C Garlanda, YM de la Torre… - Biofactors, 2009 - Wiley Online Library
Pentraxins are a family of multimeric pattern recognition proteins highly conserved in
evolution. On the basis of the primary structure of the protomer, pentraxins are divided into …

Pentraxins in innate immunity: lessons from PTX3

L Deban, S Jaillon, C Garlanda, B Bottazzi… - Cell and tissue …, 2011 - Springer
The innate immune system constitutes the first line of defence against microorganisms and
plays a primordial role in the activation and regulation of adaptive immunity. The innate …

Interactions of the humoral pattern recognition molecule PTX3 with the complement system

A Doni, C Garlanda, B Bottazzi, S Meri, P Garred… - Immunobiology, 2012 - Elsevier
The innate immune system comprises a cellular and a humoral arm. The long pentraxin
PTX3 is a fluid phase pattern recognition molecule, which acts as an essential component of …

The long pentraxin PTX3 as a key component of humoral innate immunity and a candidate diagnostic for inflammatory diseases

S Jaillon, E Bonavita, S Gentile, M Rubino… - International archives of …, 2015 - karger.com
The innate immune system is composed of a cellular arm and a humoral arm. Components
of the humoral arm include members of the complement cascade and soluble pattern …

Pentraxins as a key component of innate immunity

B Bottazzi, C Garlanda, G Salvatori, P Jeannin… - Current opinion in …, 2006 - Elsevier
Pentraxins are a complex superfamily of multifunctional molecules characterized by a
multimeric structure. C-reactive protein and pentraxin 3 (PTX3) are prototypic molecules of …

Regulation of the complement system by pentraxins

K Haapasalo, S Meri - Frontiers in immunology, 2019 - frontiersin.org
The functions of pentraxins, like C-reactive protein (CRP), serum amyloid protein P (SAP)
and pentraxin-3 (PTX3), are to coordinate spatially and temporally targeted clearance of …

Pentraxins in complement activation and regulation

YJ Ma, P Garred - Frontiers in immunology, 2018 - frontiersin.org
The complement is the first line of immune defense system involved in elimination of
invading pathogens and dying host cells. Its activation is mainly triggered by immune …

The long pentraxin PTX3: a paradigm for humoral pattern recognition molecules

A Mantovani, S Valentino, S Gentile… - Annals of the New …, 2013 - Wiley Online Library
Pattern recognition molecules (PRMs) are components of the humoral arm of innate
immunity; they recognize pathogen‐associated molecular patterns (PAMP) and are …