The participation of energy substrates in the control of meiotic maturation in murine oocytes
SM Downs, AM Mastropolo - Developmental biology, 1994 - Elsevier
In this study we have examined the effects of various energy substrate combinations on both
the maintenance of meiotic arrest and follicle-stimulating hormone (FSH)-induced germinal …
the maintenance of meiotic arrest and follicle-stimulating hormone (FSH)-induced germinal …
Glucose utilization during gonadotropin‐induced meiotic maturation in cumulus cell‐enclosed mouse oocytes
SM Downs, PG Humpherson… - Molecular …, 1996 - Wiley Online Library
Earlier work from this laboratory has determined that glucose plays an important role in the
mechanisms regulating meiotic maturation in mammalian oocytes. In the current study, we …
mechanisms regulating meiotic maturation in mammalian oocytes. In the current study, we …
Energy substrates and the completion of spontaneous meiotic maturation
SM Downs, ED Hudson - Zygote, 2000 - cambridge.org
This study was carried out to examine how different combinations of pyruvate and glucose
affect spontaneous meiotic maturation of cumulus-cell-enclosed mouse oocytes (CEO) to …
affect spontaneous meiotic maturation of cumulus-cell-enclosed mouse oocytes (CEO) to …
Substrate utilization and maturation of cumulus cell-enclosed mouse oocytes: evidence that pyruvate oxidation does not mediate meiotic induction
SM Downs, FD Houghton, PG Humpherson… - …, 1997 - rep.bioscientifica.com
This study was performed to address the possible role of pyruvate in meiotic induction in
mouse oocytes. Cumulus cell-enclosed oocytes from primed, immature mice were cultured …
mouse oocytes. Cumulus cell-enclosed oocytes from primed, immature mice were cultured …
Requirement for glucose in ligand-stimulated meiotic maturation of cumulus cell-enclosed mouse oocytes
CF Fagbohun, SM Downs - Reproduction, 1992 - rep.bioscientifica.com
In this study, the effect of different energy sources used in Eagle's minimum essential
medium on the meiotic maturation of mouse oocytes in culture was examined. The effects of …
medium on the meiotic maturation of mouse oocytes in culture was examined. The effects of …
The influence of glucose, cumulus cells, and metabolic coupling on ATP levels and meiotic control in the isolated mouse oocyte
SM Downs - Developmental biology, 1995 - Elsevier
The effects of glucose and cumulus cells on oocyte ATP levels and germinal vesicle
breakdown (GVB) in isolated mouse oocytes have been examined. Oocyte-cumulus cell …
breakdown (GVB) in isolated mouse oocytes have been examined. Oocyte-cumulus cell …
Pyruvate utilization by mouse oocytes is influenced by meiotic status and the cumulus oophorus
SM Downs, PG Humpherson… - Molecular Reproduction …, 2002 - Wiley Online Library
In this study, the effects of meiotic status on the energy substrate dynamics of mouse oocyte‐
cumulus cell complexes (OCCs) and denuded oocytes (DOs) have been examined. In the …
cumulus cell complexes (OCCs) and denuded oocytes (DOs) have been examined. In the …
Metabolism of radiolabeled glucose by mouse oocytes and oocyte-cumulus cell complexes
SM Downs, AM Utecht - Biology of reproduction, 1999 - academic.oup.com
This study was carried out to examine the metabolism of [1-14C]-,[6-14C]-, and [5-3H]
glucose by oocyte-cumulus cell complexes (OCC) and denuded oocytes (DO) and to test the …
glucose by oocyte-cumulus cell complexes (OCC) and denuded oocytes (DO) and to test the …
Culture conditions affect meiotic regulation in cumulus cell‐enclosed mouse oocytes
SM Downs, AM Mastropolo - Molecular Reproduction and …, 1997 - Wiley Online Library
To test the hypothesis that culture conditions influence meiotic regulation in mouse oocytes,
we have examined the effects of six culture media, four organic buffers, and pH on …
we have examined the effects of six culture media, four organic buffers, and pH on …
Developmental capacity of mouse oocytes following maintenance of meiotic arrest in vitro
SM Downs, AC Schroeder, JJ Eppig - Gamete research, 1986 - Wiley Online Library
It was shown previously that the frequencies of fertilization and pre‐and post‐implantation
embryonic development of mouse oocytes matured in vitro were similar to those of oocytes …
embryonic development of mouse oocytes matured in vitro were similar to those of oocytes …