In the present study, we investigated whether the peripherally acting µ-opioid receptor
agonist loperamide would inhibit allodynia in the non-inflamed dermatome of mice with …

In the present study, we investigated whether dynamic and static allodynia would be
developed in the affected dermatome in murine models of herpetic pain and postherpetic …

Percutaneous inoculation with herpes simplex virus type-1 brings about herpes zoster-like
skin lesions, tactile allodynia, and mechanical hyperalgesia in mice. This study was …

The analgesic effects of opioid agonists and the expression of μ-and κ-opioid receptors were
compared between mice with herpetic pain and those with postherpetic pain induced by …

Peripheral action of μ-opioid receptor agonist inhibits mechanical allodynia in mice with
herpetic pain. Mechanical allodynia is mainly mediated by Aβ fibers, whereas μ-opioid …

(-)-17-Cyclopropylmethyl-3, 14β-dihydroxy-4, 5α-epoxy-6β-[N-methyl-3-tran s-3-(3-furyl)
acrylamido] morphinan hydrochloride (TRK-820) is a κ-opioid receptor agonist that has …

Background The analgesic properties and mechanisms of loperamide hydrochloride, a
peripherally acting opioid receptor agonist, in neuropathic pain warrant further investigation …

Background Postherpetic neuralgia is pain that persists long after the disappearance of the
cutaneous lesions of herpes zoster. However, the mechanisms of this delayed pain are …

We have recently found that the infection with herpes simplex virus type-1 (HSV-1) of
primary sensory neurons induces nociceptive hypersensitivity to noxious mechanical …

Loperamide and three of its analogs were evaluated for their ability to inhibit binding to
cloned human opioid receptor subtypes and to produce antipruritis and antinociception …