Highlights•Inhibition of glutamine metabolism is an important mechanism in cancer
control.•Novel drugs offer a mechanism by which the key metabolic enzyme glutaminase …

Plain Language Summary Metabolic reprogramming is a major hallmark of malignant
transformation in cancer, and part of the so-called Warburg effect, in which the upregulation …

Alterations in normal metabolic processes are defining features of cancer. Glutamine, an
abundant amino acid in the human blood, plays a critical role in regulating several …

Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic
mutations and loss of tumor suppressors. Mounting evidence indicates that altered …

Metabolism rewiring is an important hallmark of cancers. Being one of the most abundant
free amino acids in the human blood, glutamine supports bioenergetics and biosynthesis …

Background: Metabolic reprogramming of tumours is a hallmark of cancer. Among the
changes in the metabolic network of cancer cells, glutaminolysis is a key reaction altered in …

The metabolic adaptations that support oncogenic growth can also render cancer cells
dependent on certain nutrients. Along with the Warburg effect, increased utilization of …

Many cancer cells exhibit an altered metabolic phenotype, in which glutamine consumption
is upregulated relative to healthy cells. This metabolic reprogramming often depends upon …

Cancer cells re-program their metabolic machinery in order to satisfy their bioenergetic and
biosynthetic requirements. A critical aspect of the re-programming of cancer cell metabolism …

Metabolic reprogramming in cancer targets glutamine metabolism as a key mechanism to
provide energy, biosynthetic precursors and redox requirements to allow the massive …