Cancer cells require a robust supply of reduced nitrogen to produce nucleotides, non-
essential amino acids and a high cellular redox activity. Glutamine provides a major …

Metabolism rewiring is an important hallmark of cancers. Being one of the most abundant
free amino acids in the human blood, glutamine supports bioenergetics and biosynthesis …

Glutamine is the most abundant circulating amino acid in blood and muscle and is critical for
many fundamental cell functions in cancer cells, including synthesis of metabolites that …

Targeted therapies against cancer have improved both survival and quality of life of patients.
However, metabolic rewiring evokes cellular mechanisms that reduce therapeutic …

Glutamine is the most abundant amino acid in blood and tissues, and the most important
nutrient except for glucose in cancer cells. Over the past years, most studies have focused …

Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic
mutations and loss of tumor suppressors. Mounting evidence indicates that altered …

Highlights•Inhibition of glutamine metabolism is an important mechanism in cancer
control.•Novel drugs offer a mechanism by which the key metabolic enzyme glutaminase …

Simple Summary Dysregulated glutamine metabolism is one of the metabolic features
evident in cancer cells when compared to normal cells. Cancer cells utilize glutamine for …

The significance of glutamine in cancer metabolism has been extensively studied. Cancer
cells consume an excessive amount of glutamine to facilitate rapid proliferation. Thus …

Cancer cells re-program their metabolic machinery in order to satisfy their bioenergetic and
biosynthetic requirements. A critical aspect of the re-programming of cancer cell metabolism …