VAR2CSA-Mediated Host Defense Evasion of Plasmodium falciparum Infected Erythrocytes in Placental Malaria
A Tomlinson, JP Semblat, B Gamain… - Frontiers in …, 2021 - frontiersin.org
Over 30 million women living in P. falciparum endemic areas are at risk of developing
malaria during pregnancy every year. Placental malaria is characterized by massive …
malaria during pregnancy every year. Placental malaria is characterized by massive …
Immunization with VAR2CSA-DBL5 Recombinant Protein Elicits Broadly Cross-Reactive Antibodies to Placental Plasmodium falciparum-Infected Erythrocytes
M Avril, MM Cartwright, MJ Hathaway… - Infection and …, 2010 - Am Soc Microbiol
Pregnancy-associated malaria is a severe clinical syndrome associated with the
sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental …
sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental …
Functional and immunological characterization of the var2CSA-DBL5ɛ domain of a placental Plasmodium falciparum isolate
S Gangnard, NGT Ndam, S Gnidehou… - Molecular and …, 2010 - Elsevier
Pregnancy-associated malaria (PAM) arises from sequestration of Plasmodium falciparum-
parasitized erythrocytes (PE) in the placenta, leading to chronic symptoms in the expectant …
parasitized erythrocytes (PE) in the placenta, leading to chronic symptoms in the expectant …
Characterization of VAR2CSA-deficient Plasmodium falciparum-infected erythrocytes selected for adhesion to the BeWo placental cell line
F Yosaatmadja, KT Andrews, MF Duffy, GV Brown… - Malaria journal, 2008 - Springer
Background Malaria in pregnancy is characterized by accumulation of infected erythrocytes
(IE) in the placenta. The key ligand identified as mediating this process is a Plasmodium …
(IE) in the placenta. The key ligand identified as mediating this process is a Plasmodium …
[HTML][HTML] Characterization of anti-var2CSA-PfEMP1 cytoadhesion inhibitory mouse monoclonal antibodies
Pregnancy-associated malaria (PAM) is associated with the massive sequestration of
erythrocytes infected with CSA-binding parasites in the placenta. Natural protective immunity …
erythrocytes infected with CSA-binding parasites in the placenta. Natural protective immunity …
VAR2CSA and protective immunity against pregnancy-associated Plasmodium falciparum malaria
People living in areas with stable transmission of P. falciparum parasites acquire protective
immunity to malaria over a number of years and following multiple disease episodes …
immunity to malaria over a number of years and following multiple disease episodes …
Identification of a major dimorphic region in the functionally critical N-terminal ID1 domain of VAR2CSA
The VAR2CSA protein of Plasmodium falciparum is transported to and expressed on the
infected erythrocyte surface where it plays a key role in placental malaria (PM). It is the …
infected erythrocyte surface where it plays a key role in placental malaria (PM). It is the …
First-Trimester Plasmodium falciparum Infections Display a Typical “Placental” Phenotype
J Doritchamou, G Bertin, A Moussiliou… - The Journal of …, 2012 - academic.oup.com
Background. Plasmodium falciparum–infected erythrocytes (IEs) adhere to host cell
receptors, allowing parasites to sequester into deep vascular beds of various organs. This …
receptors, allowing parasites to sequester into deep vascular beds of various organs. This …
Var2CSA DBL6-epsilon domain expressed in HEK293 induces limited cross-reactive and blocking antibodies to CSA binding parasites
P Fernandez, NK Viebig, S Dechavanne, C Lépolard… - Malaria Journal, 2008 - Springer
Background Pregnancy-associated malaria (PAM) is a serious consequence of Plasmodium
falciparum-infected erythrocytes sequestration in the placenta through the adhesion to the …
falciparum-infected erythrocytes sequestration in the placenta through the adhesion to the …
The immunology and pathogenesis of malaria during pregnancy
Women in endemic areas become highly susceptible to malaria during first and second
pregnancies, despite immunity acquired after years of exposure. Recent insights have …
pregnancies, despite immunity acquired after years of exposure. Recent insights have …