VAR2CSA-Mediated Host Defense Evasion of Plasmodium falciparum Infected Erythrocytes in Placental Malaria

A Tomlinson, JP Semblat, B Gamain… - Frontiers in …, 2021 - frontiersin.org
Over 30 million women living in P. falciparum endemic areas are at risk of developing
malaria during pregnancy every year. Placental malaria is characterized by massive …

Immunization with VAR2CSA-DBL5 Recombinant Protein Elicits Broadly Cross-Reactive Antibodies to Placental Plasmodium falciparum-Infected Erythrocytes

M Avril, MM Cartwright, MJ Hathaway… - Infection and …, 2010 - Am Soc Microbiol
Pregnancy-associated malaria is a severe clinical syndrome associated with the
sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental …

Functional and immunological characterization of the var2CSA-DBL5ɛ domain of a placental Plasmodium falciparum isolate

S Gangnard, NGT Ndam, S Gnidehou… - Molecular and …, 2010 - Elsevier
Pregnancy-associated malaria (PAM) arises from sequestration of Plasmodium falciparum-
parasitized erythrocytes (PE) in the placenta, leading to chronic symptoms in the expectant …

Characterization of VAR2CSA-deficient Plasmodium falciparum-infected erythrocytes selected for adhesion to the BeWo placental cell line

F Yosaatmadja, KT Andrews, MF Duffy, GV Brown… - Malaria journal, 2008 - Springer
Background Malaria in pregnancy is characterized by accumulation of infected erythrocytes
(IE) in the placenta. The key ligand identified as mediating this process is a Plasmodium …

[HTML][HTML] Characterization of anti-var2CSA-PfEMP1 cytoadhesion inhibitory mouse monoclonal antibodies

M Avril, B Gamain, C Lépolard, N Viaud, A Scherf… - Microbes and …, 2006 - Elsevier
Pregnancy-associated malaria (PAM) is associated with the massive sequestration of
erythrocytes infected with CSA-binding parasites in the placenta. Natural protective immunity …

VAR2CSA and protective immunity against pregnancy-associated Plasmodium falciparum malaria

L Hviid, A Salanti - Parasitology, 2007 - cambridge.org
People living in areas with stable transmission of P. falciparum parasites acquire protective
immunity to malaria over a number of years and following multiple disease episodes …

Identification of a major dimorphic region in the functionally critical N-terminal ID1 domain of VAR2CSA

J Doritchamou, A Sabbagh, JS Jespersen, E Renard… - PLoS …, 2015 - journals.plos.org
The VAR2CSA protein of Plasmodium falciparum is transported to and expressed on the
infected erythrocyte surface where it plays a key role in placental malaria (PM). It is the …

First-Trimester Plasmodium falciparum Infections Display a Typical “Placental” Phenotype

J Doritchamou, G Bertin, A Moussiliou… - The Journal of …, 2012 - academic.oup.com
Background. Plasmodium falciparum–infected erythrocytes (IEs) adhere to host cell
receptors, allowing parasites to sequester into deep vascular beds of various organs. This …

Var2CSA DBL6-epsilon domain expressed in HEK293 induces limited cross-reactive and blocking antibodies to CSA binding parasites

P Fernandez, NK Viebig, S Dechavanne, C Lépolard… - Malaria Journal, 2008 - Springer
Background Pregnancy-associated malaria (PAM) is a serious consequence of Plasmodium
falciparum-infected erythrocytes sequestration in the placenta through the adhesion to the …

The immunology and pathogenesis of malaria during pregnancy

JG Beeson, PE Duffy - Immunology and Immunopathogenesis of Malaria, 2005 - Springer
Women in endemic areas become highly susceptible to malaria during first and second
pregnancies, despite immunity acquired after years of exposure. Recent insights have …