The retinoblastoma gene product, pRB, regulates cell proliferation by binding to and
inhibiting the activity of key growth promoting proteins. Several cellular proteins have been …

The product of the retinoblastoma gene (RB1) is believed to function as a negative regulator
of cell growth. Recent experimental results suggest that RB1 may exert its growth …

The retinoblastoma protein (pRB) is one of the best-studied tumour suppressor gene
products. Its loss during the genesis of many human tumours, its inactivation by several DNA …

The retinoblastoma protein (pFl6) plays an important role in the control of cell proliferation,
apparently by binding to and regulating cellular transcription factors such as E2F. Here we …

Studies of naturally occurring mutations of the RB1 tumor suppressor gene have indicated
that the E1A/T antigen-binding domain is important for pRb function. Mutations engineered …

The retinoblastoma gene (RB1) is a recessive oncogene implicated in a number of human
tumors. Although the RB1 gene is expressed in most proliferating cells, there is considerable …

The retinoblastoma protein interacts with a number of cellular proteins to form complexes
which are probably crucial for its normal physiological function. To identify these proteins …

The retinoblastoma gene (RB-1) was originally identified as the gene involved in hereditary
retinoblastoma. However, RB-1 mutations are found in a number of common mesenchymal …

Studies of the retinoblastoma gene (Rb) have shown that its protein product (pRb) acts to
restrict cell proliferation, inhibit apoptosis, and promote cell differentiation. The frequent …

Genetic evidence from retinoblastoma patients and experiments describing the mechanism
of cellular transformation by the DNA tumor viruses have defined a central role for the …