Rationale Noradrenergic dysfunction is associated with disorders of impulsivity and
inattention. The rodent continuous performance test (rCPT) quantifies changes in attention …

The Cued Reinforcement Reaction Time (CRRT) task is a choice reaction time task in which
rewards (points) are available if the subject responds quickly enough and are signalled with …

The nicotinic acetylcholine receptor (nAChR) agonist nicotine and the noradrenaline
transporter inhibitor atomoxetine are widely studied substances due to their propensity to …

Rationale Impulsivity is a core symptom of attention deficit/hyperactivity disorder (ADHD).
The spontaneously hypertensive rats (SHR) is a strain commonly used as an animal model …

This 'Special issue on impulsivity and compulsivity'revisits a theme first explored by
Psychopharmacology in 1999 (146, 339–491). That issue of the journal focused on …

Rationale: Altered serotonergic and dopaminergic function have been widely implicated in
behavioural disorders associated with impulsivity and risk-taking. However, little research …

Clinical studies identify impulsivity as a defining feature of an alcohol abuse syndrome. We
recently reported an animal analogue: impulsivity assessed in a delay-of-reward paradigm …

Rationale Atomoxetine is a noradrenaline re-uptake inhibitor licensed for the treatment of
adult and childhood attention deficit hyperactivity disorder. Although atomoxetine has …

Impulsivity is characteristic of several mental health disorders and is largely mediated by the
prefrontal cortex subregions: the medial prefrontal cortex (mPFC) and the orbitofrontal cortex …

Background: Deficits in impulse control are often observed in psychiatric disorders in which
abnormalities of the prefrontal cortex are observed, including attention-deficit/hyperactivity …