The sweet and sour of serological glycoprotein tumor biomarker quantification

U Kuzmanov, H Kosanam, EP Diamandis - BMC medicine, 2013 - Springer
Aberrant and dysregulated protein glycosylation is a well-established event in the process of
oncogenesis and cancer progression. Years of study on the glycobiology of cancer have …

Glycans and glycoproteins as specific biomarkers for cancer

MJ Kailemia, D Park, CB Lebrilla - Analytical and bioanalytical chemistry, 2017 - Springer
Protein glycosylation and other post-translational modifications are involved in potentially all
aspects of human growth and development. Defective glycosylation has adverse effects on …

Glycosylation in cancer: its application as a biomarker and recent advances of analytical techniques

Y Haga, K Ueda - Glycoconjugate Journal, 2022 - Springer
Despite significant worldwide investment in research, cancer remains one of the most
common cause of death in the world. Early detection and reliable diagnosis are the keys to …

Glycoproteomics‐based identification of cancer biomarkers

EH Kim, DE Misek - International journal of proteomics, 2011 - Wiley Online Library
Protein glycosylation is one of the most common posttranslational modifications in
mammalian cells. It is involved in many biological pathways and molecular functions and is …

Glycosylation‐based serum biomarkers for cancer diagnostics and prognostics

A Kirwan, M Utratna, ME O'Dwyer… - BioMed research …, 2015 - Wiley Online Library
Cancer is the second most common cause of death in developed countries with
approximately 14 million newly diagnosed individuals and over 6 million cancer‐related …

[HTML][HTML] Aberrant protein glycosylation: Implications on diagnosis and Immunotherapy

R Bangarh, C Khatana, S Kaur, A Sharma… - Biotechnology …, 2023 - Elsevier
Glycosylation-mediated post-translational modification is critical for regulating many
fundamental processes like cell division, differentiation, immune response, and cell-to-cell …

Aberrant glycosylation and cancer biomarker discovery: a promising and thorny journey

M Wang, J Zhu, DM Lubman, C Gao - Clinical Chemistry and …, 2019 - degruyter.com
Glycosylation is among the most important post-translational modifications for proteins and
is of intrinsic complex character compared with DNAs and naked proteins. Indeed, over 50 …

Glycomic approaches for the discovery of targets in gastrointestinal cancer

S Mereiter, M Balmaña, J Gomes, A Magalhães… - Frontiers in …, 2016 - frontiersin.org
Gastrointestinal (GI) cancer is the most common group of malignancies and many of its types
are among the most deadly. Various glycoconjugates have been used in clinical practice as …

Alterations in glycosylation as biomarkers for cancer detection

CA Reis, H Osorio, L Silva, C Gomes… - Journal of clinical …, 2010 - jcp.bmj.com
Glycoconjugates constitute a major class of biomolecules which include glycoproteins,
glycosphingolipids and proteoglycans. Glycans are involved in several physiological and …

Technologies and strategies for glycoproteomics and glycomics and their application to clinical biomarker research

F Tousi, WS Hancock, M Hincapie - Analytical Methods, 2011 - pubs.rsc.org
Several approaches and technologies are currently available to study the glycosylated
proteome (glycoproteomics) or the entire repertoire of glycans in a biological system …