Baroreflex activation therapy for the treatment of heart failure with a reduced ejection fraction

WT Abraham, MR Zile, FA Weaver, C Butter… - JACC: Heart Failure, 2015 - jacc.org
Objectives: The objective of this clinical trial was to assess the safety and efficacy of carotid
BAT in advanced HF. Background: Increased sympathetic and decreased parasympathetic …

Baroreflex activation therapy in patients with heart failure with reduced ejection fraction

MR Zile, JA Lindenfeld, FA Weaver, F Zannad… - Journal of the American …, 2020 - jacc.org
Background This study demonstrated the safety and effectiveness of baroreflex activation
therapy (BAT) in patients with heart failure with reduced ejection fraction (HFrEF). Objectives …

Baroreflex activation therapy for the treatment of heart failure with a reduced ejection fraction: safety and efficacy in patients with and without cardiac resynchronization …

MR Zile, WT Abraham, FA Weaver… - European journal of …, 2015 - Wiley Online Library
Aims Increased sympathetic and decreased parasympathetic activity contribute to heart
failure (HF) symptoms and disease progression. Carotid baroreceptor stimulation (baroreflex …

Chronic baroreflex activation: a potential therapeutic approach to heart failure with preserved ejection fraction

D Georgakopoulos, WC Little, WT Abraham… - Journal of cardiac …, 2011 - Elsevier
Heart failure with preserved ejection fraction (HFpEF) is a substantial public health issue,
equal in magnitude to heart failure with reduced ejection fraction. Clinical outcomes of …

Chronic baroreflex activation effects on sympathetic nerve traffic, baroreflex function, and cardiac haemodynamics in heart failure: a proof‐of‐concept study

E Gronda, G Seravalle, G Brambilla… - European journal of …, 2014 - Wiley Online Library
Aims Heart failure (HF) pathophysiology is believed to be mediated by autonomic
dysfunction, including chronic sympathoexcitation and diminished baroreflex sensitivity …

Baroreflex activation therapy with the Barostim™ device in patients with heart failure with reduced ejection fraction: a patient level meta‐analysis of randomized …

AJS Coats, WT Abraham, MR Zile… - European Journal of …, 2022 - Wiley Online Library
Aims Heart failure with reduced ejection fraction (HFrEF) remains associated with high
morbidity and mortality, poor quality of life (QoL) and significant exercise limitation …

Baroreflex activation and cardiac resynchronization for heart failure treatment

RS Kieval, MA Rossing, ED Irwin, JR Brintnall - 2006 - Google Patents
WO2006041664A2 - Baroreflex activation and cardiac resynchronization for heart failure treatment
- Google Patents WO2006041664A2 - Baroreflex activation and cardiac resynchronization for …

Baroreflex activation therapy lowers blood pressure in patients with resistant hypertension: results from the double-blind, randomized, placebo-controlled rheos pivotal …

JD Bisognano, G Bakris, MK Nadim, L Sanchez… - Journal of the American …, 2011 - jacc.org
Objectives: We sought to determine the effect of baroreflex activation therapy (BAT) on
systolic blood pressure (SBP) in patients with resistant hypertension. Background: The …

[HTML][HTML] Autonomic regulation therapy for the improvement of left ventricular function and heart failure symptoms: the ANTHEM-HF study

L Dicarlo, I Libbus, B Amurthur, BH Kenknight… - Journal of cardiac …, 2013 - Elsevier
Background Outcomes of heart failure (HF) have improved dramatically with the use of
blockers of the sympathetic and renin-angiotensin-aldosterone systems, as well as with …

Impact of autonomic regulation therapy in patients with heart failure: ANTHEM-HFrEF pivotal study design

MA Konstam, JE Udelson, J Butler, HU Klein… - Circulation: Heart …, 2019 - Am Heart Assoc
Background: The ANTHEM-HFrEF (Autonomic Regulation Therapy to Enhance Myocardial
Function and Reduce Progression of Heart Failure with Reduced Ejection Fraction) pivotal …