The recent discovery that a small number of defined factors are sufficient to reprogram
somatic cells into pluripotent stem cells has significantly expanded our knowledge of the …

Reprogramming of somatic cells to induced pluripotent stem cells involves a dynamic
rearrangement of the epigenetic landscape. To characterize this epigenomic roadmap, we …

Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) is a
comprehensive epigenetic process involving genome-wide modifications of histones and …

Global DNA demethylation is an integral part of reprogramming processes in vivo and in
vitro, but whether it occurs in the derivation of induced pluripotent stem cells (iPSCs) is not …

Embryonic stem cells have the unique ability to indefinitely self-renew and differentiate into
any cell type found in the adult body. Differentiated cells can, in turn, be reprogrammed to …

Induced pluripotent stem cells (iPSCs) are generated from somatic cells by the transduction
of defined transcription factors, and this process involves dynamic changes in DNA …

The epigenetic dynamics of induced pluripotent stem cell (iPSC) reprogramming in correctly
reprogrammed cells at high resolution and throughout the entire process remain largely …

Epigenetic modifications constitute a complex regulatory layer on top of the genome
sequence. Pluripotent and differentiated cells provide a powerful system for investigating …

Transcription-factor-directed reprogramming from somatic cells to induced pluripotent stem
cells (iPSCs) is by nature an epigenetic process of cell fate change. Previous studies have …

Reprogramming of somatic cell nuclei to yield induced pluripotent stem (iPS) cells makes
possible derivation of patient-specific stem cells for regenerative medicine. However, iPS …