Obesity and associated metabolic diseases have become a priority area of study due to the
exponential increase in their prevalence and the corresponding health and economic …

In homoeothermic organisms, the preservation of core temperature represents a primal
function, and its costs in terms of energy expenditure can be considerable. In modern …

According to the adipostat hypothesis for body-weight control, alterations in body weight
should always be compensated by adequate alterations in food intake and thermogenesis …

An increase in energy intake and/or a decrease in energy expenditure lead to fat storage,
causing overweight and obesity phenotypes. The objective of this review was to analyse, for …

There is a rapidly increasing prevalence of obesity and related metabolic disorders such as
type 2 diabetes worldwide. White adipose tissue (WAT) stores excess energy, whereas …

Brown adipose tissue from mice living under conditions approaching human thermal and
nutritional conditions (prolonged exposure to thermoneutral temperature and to an energy …

Brown/beige adipocytes are therapeutic targets to combat obesity due to their abilities to
dissipate energy through adaptive thermogenesis. Most studies investigating induction of …

Brown fat is emerging as an interesting and promising target for therapeutic intervention in
obesity and metabolic disease. Activation of brown fat in humans is associated with marked …

Brown and beige adipose tissues play a large role in non-shivering thermogenesis (NST) in
mammals, and subsequently have been studied for decades as potential therapeutic targets …

Large inter‐individual differences in cold‐induced (non‐shivering) and diet‐induced
adaptive thermogenesis exist in animals and humans. These differences in energy …