Sleep is vital for maintaining health and well-being; however, insomnia is currently a
widespread health complaint. According to a report from the National Sleep Foundation in …

Sleep is an essential component of physical and emotional well-being, and lack, or
disruption, of sleep due to insomnia is a highly prevalent problem. The interest in …

Insomnia is a common sleep disorder. Natural sleep aids are gaining worldwide popularity
as alternatives to prescription drugs for improving sleep. Recently, numerous studies have …

Although drugs such as barbiturates and benzodiazepines are often used for the treatment
of insomnia, they are associated with various side effects such as habituations, tolerance …

Rationale In psychopharmacology, researchers have been interested in the hypnotic effects
of terrestrial plant polyphenols and their synthetic derivatives. Phlorotannins, a marine plant …

In our previous studies, we have demonstrated that marine polyphenol phlorotannins
promote sleep through the benzodiazepine site of the gamma-aminobutyric acid type A …

We had previously demonstrated that phlorotannins, which are marine polyphenols,
enhance sleep in mice via the GABAA-benzodiazepine (BZD) receptor. Among the …

Insomnia is a common sleep disorder which is prevalent in women and the elderly. Current
insomnia drugs mainly target the γ-aminobutyric acid (GABA) receptor, melatonin receptor …

In our previous studies, a standardized phlorotannin (brown seaweed polyphenol)
supplement (PS) exhibited sleep-promoting effects via type A γ-aminobutyric acid …

Global epidemiologic evidence supports an interrelationship between sleep disorders and
fruits and vegetable ingestion. Polyphenols, a broad group of plant substances, are …