The retinoblastoma (RB) gene encodes a nuclear phosphoprotein with a molecular weight
of 110,000 (pp110RB) associated with DNA-binding activity. This sequence-nonspecific …

We have previously identified a small-cell lung cancer cell line (NCI-H209) that expresses
an aberrant, underphosphorylated form of the retinoblastoma protein RB1. Molecular …

The retinoblastoma (RB) gene encodes a nuclear phosphoprotein of 928 amino acids
(pRB). Thus far, much effort in RB research has been focused on both the viral oncoprotein …

The product of the retinoblastoma susceptibility gene (RB) was overproduced in cultured
insect cells using the baculovirus expression system. Upon insertion of the cloned human …

A SUBSTANTIAL BODY of cancer research literature provides evidence that the
retinoblastoma gene (RB) on chromosome 13 suffers germline and somatic mutations that …

Mutational inactivation of the retinoblastoma (RB) gene has been implicated in the genesis
of retinoblastoma, osteosarcoma, and other human tumors. Our strategy has been to …

A class of cellular genes in which loss-of-function mutations are tumorigenic has been
proposed. Such genes would normally act to suppress the cancer phenotype at the cellular …

Rb protein was purified from recombinant baculovirus-infected Sf9 cells to apparent
homogeneity by a simple solubilization and by immunoaffinity column chromatography. It …

A missense mutation at cysteine 706, resulting in a retinoblastoma (RB) protein defective in
phosphorylation and oncoprotein binding, has been isolated from a human tumor cell line …

Retinoblastoma, an uncommon childhood cancer of the eye, sometimes occurs in families
but is often sporadic. Cytological analysis suggested that the retinoblastoma gene resided …