Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation
Activated glial cells (microglia and astroglia) in the spinal cord play a major role in mediating
enhanced pain states by releasing proinflammatory cytokines and other substances thought …
enhanced pain states by releasing proinflammatory cytokines and other substances thought …
Intrathecal minocycline attenuates peripheral inflammation‐induced hyperalgesia by inhibiting p38 MAPK in spinal microglia
XY Hua, CI Svensson, T Matsui… - European Journal of …, 2005 - Wiley Online Library
Activation of p38 mitogen‐activated protein kinase (p38) in spinal microglia is implicated in
spinal nociceptive processing. Minocycline, a tetracycline derivative, displays selective …
spinal nociceptive processing. Minocycline, a tetracycline derivative, displays selective …
Minocycline prevents the development of neuropathic pain, but not acute pain: possible anti-inflammatory and antioxidant mechanisms
SSV Padi, SK Kulkarni - European journal of pharmacology, 2008 - Elsevier
Glia, particularly astrocytes and microglia, are known to play an important role in central
sensitization and are strongly implicated in the exaggerated pain states. In the present study …
sensitization and are strongly implicated in the exaggerated pain states. In the present study …
Differential activation of spinal microglial and astroglial cells in a mouse model of peripheral neuropathic pain
J Mika, M Osikowicz, E Rojewska, M Korostynski… - European journal of …, 2009 - Elsevier
The pharmacological attenuation of glial activation represents a novel approach for
controlling neuropathic pain, but the role of microglial and astroglial cells is not well …
controlling neuropathic pain, but the role of microglial and astroglial cells is not well …
Activated microglia contribute to the maintenance of chronic pain after spinal cord injury
BC Hains, SG Waxman - Journal of Neuroscience, 2006 - Soc Neuroscience
Traumatic spinal cord injury (SCI) results not only in motor impairment but also in chronic
central pain, which can be refractory to conventional treatment approaches. It has been …
central pain, which can be refractory to conventional treatment approaches. It has been …
Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain
J Mika, M Osikowicz, W Makuch… - European journal of …, 2007 - Elsevier
Recent research has shown that microglial cells which are strongly activated in neuropathy
can influence development of allodynia and hyperalgesia. Here we demonstrated that …
can influence development of allodynia and hyperalgesia. Here we demonstrated that …
Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy
V Raghavendra, F Tanga, JA DeLeo - Journal of Pharmacology and …, 2003 - ASPET
Microglia, the intrinsic macrophages of the central nervous system, have previously been
shown to be activated in the spinal cord in several rat mononeuropathy models. Activation of …
shown to be activated in the spinal cord in several rat mononeuropathy models. Activation of …
The contribution of spinal glial cells to chronic pain behaviour in the monosodium iodoacetate model of osteoarthritic pain
DR Sagar, JJ Burston, GJ Hathway… - Molecular …, 2011 - journals.sagepub.com
Background: Clinical studies of osteoarthritis (OA) suggest central sensitization may
contribute to the chronic pain experienced. This preclinical study used the monosodium …
contribute to the chronic pain experienced. This preclinical study used the monosodium …
HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS)
It has become clear that spinal cord glia (microglia and astrocytes) importantly contribute to
the creation of exaggerated pain responses. One model used to study this is peri-spinal …
the creation of exaggerated pain responses. One model used to study this is peri-spinal …
Minocycline modulates neuropathic pain behaviour and cortical M1–M2 microglial gene expression in a rat model of depression
There is a paucity of data on the role of microglia and neuroinflammatory processes in the
association between chronic pain and depression. The current study examined the effect of …
association between chronic pain and depression. The current study examined the effect of …