Despite its potential clinical impact, intra-tumor genetic heterogeneity (ITH) has been scantly
investigated in papillary thyroid cancer (PTC). We studied ITH in PTC by combining, for the …

Background: The need to integrate the classification of cancer with information on the
genetic pattern has emerged in recent years for several tumors. Methods: The genomic …

Intratumoral heterogeneity (ITH) refers to a subclonal genetic diversity observed within a
tumor. ITH is the consequence of genetic instability and accumulation of genetic alterations …

Unlike many cancers, the pattern of tumor evolution in papillary thyroid cancer (PTC) and its
potential role in relapse have not been elucidated. In this study, multi-region whole-exome …

Background Intra-tumor heterogeneity (ITH) results from the continuous accumulation of
mutations during disease progression, thus impacting patients' clinical outcome. How the …

Purpose To evaluate the application of whole genome sequencing (WGS) in determining the
inter-foci clonal relationship of multifocal papillary thyroid carcinoma (mPTC). Methods After …

Background: Papillary thyroid cancer (PTC) is reported to be highly heritable in
epidemiological studies. Genome-wide association studies (GWAS) have uncovered several …

The incidence of papillary thyroid carcinomas (PTCs) has increased rapidly during the past
several decades. Until now, the mechanisms underlying the tumorigenesis of PTCs have …

Papillary thyroid carcinoma (PTC) is frequently multifocal (mPTC), with synchronous tumour
foci often showing varied morphology. The genetic mechanisms underlying the development …

Papillary thyroid carcinoma (PTCa) is a relatively common, indolent tumor that usually has
an excellent prognosis. While the diagnosis of conventional PTCa is relatively …