Cytosine methylation is an epigenetic mechanism in eukaryotes that is often associated with
stable transcriptional silencing, such as in X-chromosome inactivation and genomic …

Recent research highlights the role of CpG methylation in genomic imprinting, histone and
chromatin modification, transcriptional regulation, and 'gene silencing'in cancer …

DNA methylation has been comprehensively profiled in normal and cancer cells, but the
dynamics that form, maintain and reprogram differentially methylated regions remain …

Cytosine methylation is widespread among organisms and essential for mammalian
development. In line with early postulations of an epigenetic role in gene regulation …

DNA methylation is one of the most extensively studied epigenetic marks. It is involved in
transcriptional gene silencing and plays important roles during mammalian development. Its …

DNA cytosine methylation is a central epigenetic marker that is usually mutagenic and may
increase the level of sequence divergence. However, methylated genes have been reported …

Background There is growing evidence that DNA methylation alterations contribute to
carcinogenesis. While cancer tissue exhibits widespread DNA methylation changes, the …

DNA methylation is an essential epigenetic mark whose role in gene regulation and its
dependency on genomic sequence and environment are not fully understood. In this study …

Metastable and somatically heritable patterns of DNA methylation provide an important level
of genomic regulation. In this article, we review methods for analyzing these genome-wide …

Abstract Motivation: Methylation of CpG dinucleotides is a prevalent epigenetic modification
that is required for proper development in vertebrates. Genome-wide DNA methylation …