Phosphoinositide-3-kinase/akt survival signal pathways are implicated in neuronal survival after stroke
H Zhao, RM Sapolsky, GK Steinberg - Molecular neurobiology, 2006 - Springer
In recent years, the phosphoinositide-3-kinase/Akt cell survival signaling pathway has been
increasingly researched in the field of stroke. Akt activity is suggested to be upregulated by …
increasingly researched in the field of stroke. Akt activity is suggested to be upregulated by …
Akt contributes to neuroprotection by hypothermia against cerebral ischemia in rats
H Zhao, T Shimohata, JQ Wang, G Sun… - Journal of …, 2005 - Soc Neuroscience
Activation of the Akt/protein kinase B (PKB) kinase pathway can be neuroprotective after
stroke. Akt is activated by growth factors via a phosphorylation-dependent pathway involving …
stroke. Akt is activated by growth factors via a phosphorylation-dependent pathway involving …
Activation of the Akt/GSK3β signaling pathway mediates survival of vulnerable hippocampal neurons after transient global cerebral ischemia in rats
H Endo, C Nito, H Kamada, T Nishi… - Journal of Cerebral …, 2006 - journals.sagepub.com
Recent studies have revealed that the phosphatidylinositol 3-kinase (PI3-K) pathway is
involved in apoptotic cell death after experimental cerebral ischemia. The serine—threonine …
involved in apoptotic cell death after experimental cerebral ischemia. The serine—threonine …
Crosstalk between MAPK/ERK and PI3K/AKT signal pathways during brain ischemia/reperfusion
J Zhou, T Du, B Li, Y Rong, A Verkhratsky… - ASN neuro, 2015 - journals.sagepub.com
The epidermal growth factor receptor (EGFR) is linked to the phosphatidylinositol 3-kinase
(PI3K)/protein kinase B (AKT) and Raf/mitogen-activated protein kinase (MAPK)/extracellular …
(PI3K)/protein kinase B (AKT) and Raf/mitogen-activated protein kinase (MAPK)/extracellular …
Therapeutic modulation of the phosphatidylinositol 3-kinases (PI3K) pathway in cerebral ischemic injury
The cerebral ischemic reperfusion injury may leads to morbidity and mortality in patients.
phosphatidylinositol 3-kinase (PI3K) signaling pathway has been believed to work in …
phosphatidylinositol 3-kinase (PI3K) signaling pathway has been believed to work in …
[HTML][HTML] Critical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injury
QG Zhang, DN Wu, D Han, GY Zhang - FEBS letters, 2007 - Elsevier
JNK pathway is an important pro-apoptotic kinase cascade mediating cell death in response
to a variety of extracellular stimuli including excitotoxicity, which results in selective and …
to a variety of extracellular stimuli including excitotoxicity, which results in selective and …
Akt isoforms differentially protect against stroke-induced neuronal injury by regulating mTOR activities
Protein kinases Akt1 and Akt3 are considered to be more crucial to brain function than Akt2.
We investigated the roles of Akt1 and Akt3 in stroke-induced brain injury and examined their …
We investigated the roles of Akt1 and Akt3 in stroke-induced brain injury and examined their …
The neuroprotection of insulin on ischemic brain injury in rat hippocampus through negative regulation of JNK signaling pathway by PI3K/Akt activation
Current studies demonstrated that cell survival is determined by a balance among signaling
cascades, including those that recruit the Akt and JNK pathways. In our present work, the …
cascades, including those that recruit the Akt and JNK pathways. In our present work, the …
Alterations of Akt1 (PKBα) and p70S6K in transient focal ischemia
S Janelidze, BR Hu, P Siesjö, BK Siesjö - Neurobiology of disease, 2001 - Elsevier
The serine-threonine kinase Akt1 promotes cell survival through inhibition of apoptosis. One
of the potential downstream targets of Akt1 is p70 S6 kinase, p70S6K, an enzyme implicated …
of the potential downstream targets of Akt1 is p70 S6 kinase, p70S6K, an enzyme implicated …
The Akt signaling pathway contributes to postconditioning's protection against stroke; the protection is associated with the MAPK and PKC pathways
X Gao, H Zhang, T Takahashi, J Hsieh… - Journal of …, 2008 - Wiley Online Library
We previously reported that ischemic postconditioning with a series of mechanical
interruptions of reperfusion reduced infarct volume 2 days after focal ischemia in rats. Here …
interruptions of reperfusion reduced infarct volume 2 days after focal ischemia in rats. Here …