In recent years, the phosphoinositide-3-kinase/Akt cell survival signaling pathway has been
increasingly researched in the field of stroke. Akt activity is suggested to be upregulated by …

Activation of the Akt/protein kinase B (PKB) kinase pathway can be neuroprotective after
stroke. Akt is activated by growth factors via a phosphorylation-dependent pathway involving …

Recent studies have revealed that the phosphatidylinositol 3-kinase (PI3-K) pathway is
involved in apoptotic cell death after experimental cerebral ischemia. The serine—threonine …

The epidermal growth factor receptor (EGFR) is linked to the phosphatidylinositol 3-kinase
(PI3K)/protein kinase B (AKT) and Raf/mitogen-activated protein kinase (MAPK)/extracellular …

The cerebral ischemic reperfusion injury may leads to morbidity and mortality in patients.
phosphatidylinositol 3-kinase (PI3K) signaling pathway has been believed to work in …

JNK pathway is an important pro-apoptotic kinase cascade mediating cell death in response
to a variety of extracellular stimuli including excitotoxicity, which results in selective and …

Protein kinases Akt1 and Akt3 are considered to be more crucial to brain function than Akt2.
We investigated the roles of Akt1 and Akt3 in stroke-induced brain injury and examined their …

Current studies demonstrated that cell survival is determined by a balance among signaling
cascades, including those that recruit the Akt and JNK pathways. In our present work, the …

The serine-threonine kinase Akt1 promotes cell survival through inhibition of apoptosis. One
of the potential downstream targets of Akt1 is p70 S6 kinase, p70S6K, an enzyme implicated …

We previously reported that ischemic postconditioning with a series of mechanical
interruptions of reperfusion reduced infarct volume 2 days after focal ischemia in rats. Here …