The effects of ambient particulate matter on human alveolar macrophage oxidative and inflammatory responses

K Sawyer, S Mundandhara, AJ Ghio… - Journal of Toxicology …, 2009 - Taylor & Francis
Epidemiologic and occupational studies demonstrated that ambient particulate matter (PM)
and diesel exhaust particles (DEP) exert deleterious effects on human cardiopulmonary …

Effects of diesel exhaust particles on human alveolar macrophage ability to secrete inflammatory mediators in response to lipopolysaccharide

SD Mundandhara, S Becker, MC Madden - Toxicology in vitro, 2006 - Elsevier
Ambient particulate matter (PM) has been shown to be associated with mortality and
morbidity. Diesel exhaust particles (DEP) contribute to ambient PM. Alveolar macrophages …

Stimulation of human and rat alveolar macrophages by urban air particulates: effects on oxidant radical generation and cytokine production

S Becker, JM Soukup, MI Gilmour, RB Devlin - Toxicology and applied …, 1996 - Elsevier
A number of epidemiological studies have associated increased cardiopulmonary mortality
and hospital admissions with episodes of high particulate air pollution. Inhaled particles …

Reactive oxygen species in pulmonary inflammation by ambient particulates

F Tao, B Gonzalez-Flecha, L Kobzik - Free Radical Biology and Medicine, 2003 - Elsevier
Exposure to ambient air pollution particles (PM) has been associated with increased
cardiopulmonary morbidity and mortality, particularly in individuals with pre-existing disease …

Seasonal variations in air pollution particle-induced inflammatory mediator release and oxidative stress

S Becker, LA Dailey, JM Soukup… - Environmental …, 2005 - ehp.niehs.nih.gov
Health effects associated with particulate matter (PM) show seasonal variations. We
hypothesized that these heterogeneous effects may be attributed partly to the differences in …

Analysis of air pollution particulate-mediated oxidant stress in alveolar macrophages

CAWGA Imrich, HDYY Ning - Journal of Toxicology and …, 1998 - Taylor & Francis
Adverse health effects of urban air pollution particulates may be attributable to particle
mediated oxidant stress and inflammation. Intracellular oxidant production in normal …

[PDF][PDF] The role of reactive oxygen species and oxidative stress in mediating particulate matter injury

T Xia, M Kovochich, A Nel - Clin Occup Environ Med, 2006 - academia.edu
Several plausible mechanisms have been proposed to explain the adverse health effects of
particulate matter (PM) in polluted ambient air [1]. To date, experimental support has been …

Effects of diesel exhaust particles (DEP), carbon black, and silica on macrophage responses to lipopolysaccharide: evidence of DEP suppression of macrophage …

HM Yang, MW Barger, V Castranova… - Journal of Toxicology …, 1999 - Taylor & Francis
The effects of diesel exhaust particle (DEP) exposure on alveolar macrophage (AM)
response to ex vivo and in vivo lipopolysaccharide (LPS) challenge were determined by …

Exposure to urban air particulates alters the macrophage-mediated inflammatory response to respiratory viral infection

S Becker, JM Soukup - … Toxicology and Environmental Health Part A, 1999 - Taylor & Francis
Epidemiology studies associate increased pulmonary morbidity with episodes of high
particulate air pollution (size range 0.1-10 mum diameter, PM10). Pneumonia, often viral in …

Cytotoxic and proinflammatory effects of ambient and source-related particulate matter (PM) in relation to the production of reactive oxygen species (ROS) and …

US Akhtar, RD McWhinney, N Rastogi… - Inhalation …, 2010 - Taylor & Francis
The composition of airborne particulate matter (PM) varies widely depending on its source,
and recent studies have suggested that particle-associated adverse health effects are …