Progressive accumulation of genetic mutations is thought to be central to the process of
tumorigenesis and aging (1). Most of the critical genes that are mutated during the …

A workshop was held to discuss the uses of data on DNA adduct measurement in humans
and in experimental systemsin vitroandin vivo. The discussions focused principally on the …

Human exposure to DNA damaging agents can arise from exogenous sources or
endogenous processes that occur normally or in pathological states. DNA isolated from …

The reaction of chemical carcinogens with DNA appears to be one of the earliest events in
the initiation phase of cancer. These DNA reactions can be base-and position-specific, are …

During the 30 years or so following the identification of the first pure chemical carcinogen
(1), no common factors or pathways in the mechanism of action of carcinogens from different …

The genome and its nucleotide precursor pool are under sustained attack by radiation,
reactive oxygen and nitrogen species, chemical carcinogens, hydrolytic reactions, and …

Recent improvements in the ability to detect chemically modified bases in DNA have
revealed that not only does the genetic material incur damage by foreign chemicals, but that …

DNA damage plays a major role in mutagenesis, carcinogenesis and ageing. The vast
majority of mutations in human tissues are certainly of endogenous origin. A thorough …

Quantitation of DNA adducts in human tissues has been achieved with highly sensitive
techniques based on adduct radiolabeling, antisera specific for DNA adducts or modified …

The reaction of DNA-damaging agents with the genome results in a plethora of lesions,
commonly referred to as adducts. Adducts may cause DNA to mutate, they may represent …