Cryptococcal meningitis is a devastating HIV-related opportunistic infection, affecting nearly
1 million individuals and causing over 500 000 deaths each year. The burden of disease is …

Cryptococcal meningitis is a leading cause of meningitis in sub-Saharan Africa. Given the
need for rapid point-of-care testing, we evaluated the diagnostic performance of the …

Importance of field: Cryptococcal meningitis is a leading cause of death globally among
people with AIDS. In sub-Saharan Africa, cryptococcosis is estimated to kill more people …

Current diagnostics for Cryptococcal meningitis (CM) rely on India ink, CSF culture, or
cryptococcal antigen (CRAG) latex agglutination test. India ink is relatively insensitive …

Since rapid cryptococcal antigen lateral flow assays (CrAg LFA) may expedite treatment of
HIV-associated cryptococcal infections, we sought to validate clinic-based CrAg LFA testing …

Despite access to antiretroviral therapy, mortality from cryptococcal meningitis (CM) is high
among persons with advanced HIV infection in sub‐Saharan Africa. Cryptococcal antigen …

Early cryptococcal disease can be detected via circulating antigen in blood before fulminant
meningitis develops, when early antifungal therapy improves survival. Two semiquantitative …

Over the past ten years, standard diagnostics for cryptococcal meningitis in HIV-infected
persons have evolved from culture to India ink to detection of cryptococcal antigen (CrAg) …

Background HIV-associated cryptococcal meningitis is the leading cause of adult meningitis
in Sub-Saharan Africa, accounting for 15%–20% of AIDS-attributable mortality. The …

Cryptococcal epidemiology is shifting toward HIV-negative populations who have diverse
presentations. Cryptococcal antigen (CrAg) testing is also changing, with development of the …