There is tremendous ferment in the field of epigenetics as the relationships between
chromatin structure and DNA methylation patterns become clearer. Central to this activity is …

An understanding of the function and control of DNA methylation in eukaryotes has been
elusive. Studies of Neurospora crassa have led to a model that accounts for the …

Over three decades ago DNA methylation had been suggested to play a role in the
regulation of gene expression. This chapter reviews the development of this field of research …

DNA methylation, chromatin structure, transcription, and cancer have traditionally been
studied as separate phenomena. Recent data provide now direct physical and functional …

Methylation of cytosines silences transposable elements and selected cellular genes in
mammals, plants, and some fungi. Recent findings have revealed mechanistic connections …

Background: The heterochromatin of many eukaryotes is marked by both DNA methylation
and histone H3 lysine 9 (H3-K9) methylation, though the exact relationship between these …

Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene
silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be …

Research in cancer epigenomics is driven by the development of novel technologies and
the utilization of model organisms ranging from yeasts to plants to vertebrates. For decades …

DNA methylation is commonly associated with gene silencing, and a link between histone
deacetylation and DNA methylation has been established. However, the transcriptional …

Both DNA methylation and histone modification are involved in establishing patterns of gene
repression during development. Certain forms of histone methylation cause local formation …