Tumor heterogeneity is an important feature of malignant tumors, and cell subpopulations
may positively interact to facilitate tumor progression. Studies have shown that hypoxic …

Background: Colorectal cancer (CRC) is most common malignancy worldwide, and its
underlying molecular mechanisms remain largely unexplored. Accumulating evidences …

Purpose Hypoxia has been found to play an important role in regulating the biological
characteristics of cancer stem cells (cCSCs). In this study, we tested whether a tumor …

Background: Intratumoral hypoxia is known to lead to increased aggressiveness and distant
metastasis. However, the interplay underlying these actions is still unknown. Objective: We …

Hypoxia and serum depletion are common features of solid tumors that occur upon
antiangiogenesis, irradiation and chemotherapy across a wide variety of malignancies. Here …

Two main features common to all solid tumors are tissue hypoxia and inflammation, both of
which cause tumor progression, metastasis, therapy resistance and increased mortality …

In colon cancer, the prognostic value of macrophages is controversial, and it is still unknown
how hypoxia modulates macrophage–cancer cell crosstalk. To unravel this, co-cultures of …

Uneven oxygen supply in solid tumors leads to hypoxic and normoxic regions. Hypoxic cells
exhibit increased secretion of lactate, which creates an acidic tumor microenvironment …

Colorectal cancer patients often relapse after chemotherapy, owing to the survival of stem or
progenitor cells referred to as cancer stem cells (CSCs). Although tumor stromal factors are …

Although CD133 is a representative cancer stem cell marker, its function in tumor
aggressiveness under hypoxia remains unclear. Therefore, the present study aimed to …