Objectives Topical lidocaine is effective in postherpetic neuralgia (PHN). The aim of the
present investigation was to classify patients according to their predominant peripheral …

Background Evidence for a role of immune system in hyperalgesic pain states is increasing.
Recent work in neuroimmunology suggests that the immune system does more than simply …

Postherpetic neuralgia (PHN) following herpes zoster is a common and disabling
neuropathic pain syndrome. In a double‐blind, three‐session study, 5% lidocaine gel or …

Recent studies have revealed that T lymphocytes play a role in neuropathic pain following
nerve injury in rats through releasing several cytokines. Sirolimus is an immunosuppressive …

Objective To investigate the possible mechanisms of topical analgesics in relieving pain in
an animal model of muscular inflammation. Methods Adult Sprague-Dawley rats of both …

Aspirin (ASA) is a widely used oral analgesic which acts as an inhibitor of cyclooxygenase.
Acetaminophen (ACET) is also an effective analgesic and may selectively inhibit brain …

The contribution of the activity of afferent fiber filaments to pain and hyperalgesia after
administration of a plantar injection of interleukin-1β (IL-1β) to the hind-paw skin was …

MATERIALS AND METHODS Animals Male ICR mice (SLC, Osaka, Japan) weighting 20—
22 g were used. They were housed in plastic cages with water and food available ad libitum …

The modulation of behavioral responses evoked by local and distant nociceptive stimuli
following a discrete somatic injection of complete Freund's adjuvant (CFA) was examined in …

抄録 We investigated the effects of OT-7100, a novel analgesic compound (5-n-butyl-7-(3, 4,
5-trimethoxybenzoylamino) pyrazolo [1, 5-a] pyrimidine), on prostaglandin E 2 biosynthesis …