Background. Human breast cancers frequently show loss of heterozygosity (LOH) and/or
amplification at specific chromosomal regions. Methods. To investigate the roles of these …

In order to detect common regions of deletion, 219 breast tumors were examined for loss of
heterozygosity at several loci on chromosomes 3p, 16q, and 17 by restriction fragment …

All human chromosomes were screened in 52 human breast carcinomas for the occurrence
of allele losses, in order to identify genomic alterations involved in initiation and progression …

Loss of heterozygosity (LOH), which is detected with polymorphic DNA markers by
comparing constitutional and tumor genotypes, has been observed at a number of different …

During the past five years, important progress has been made in the identification of genes
and/or chromosomal rearrangements that may have direct relevance for the development of …

Chromosomal abnormalities have been implicated in cancer development since the turn of
the last century. Only during the past two decades, with advances in cytogenetics and …

We have undertaken a systematic study of primary human breast tumor DNAa to identify and
characterize frequently occurring somatic mutations. Loss of heterozygosity (LOH) was …

Genetic alterations that occur in human breast cancers are believed to be of importance for
initiation as well as progression of the disease. In order to find a genetic alteration that may …

We review and discuss data on the genetic alterations documented in human breast
carcinomas at the molecular level. These alterations may result in: 1) deletion of genetic …

A serious effort has been made to identify and characterize mutations that frequently occur
during the evolution of primary human breast cancer. Some of these mutations involve …