Rearrangements or loss of chromosome 17 are frequent events in breast tumors.
Chromosome 17 contains at least four genes implicated in breast cancer (TP53, ERBB2 …

This review is focused on genetic factors that may influence the development and/or
appearance of breast cancer metastases. Over the last decade there have been significant …

A number of gene and chromosome alterations have been identified in sporadic breast
carcinomas, and their clinical implications have been investigated. Changes in proto …

Loss of heterozygosity (LOH) at 7q31 has been claimed to occur in over 80% of all breast
cancers and to be of prognostic significance. This would make this genetic alteration the …

Background Breast cancer is characterized by complex genetic alterations found in multiple
chromosomal regions, most commonly losses of 17p, 16q, 8p and others. A number of tumor …

Between 5% and 10% of breast cancer cases can be traced to primary genetic factors.
Before the discovery of the BRCA1 and BRCA2 genes, if a first-degree relative in direct …

DNA copy number changes were characterized by comparative genomic hybridization
(CGH) in 18 breast cancer cell lines. In 5 of these, the results were comparable with those …

While it has long been recognized that a proportion of breast cancer cases are the result of
an inherited familial predisposition, precise knowledge of the underlying genetic processes …

Familial breast cancer was first recognized in the Roman medical literature of 100 AD [1]. It
is therefore surprising that in spite of this early historical perspective, very little attention was …

Multiple etiology and morbidity risks may be masked when a specific lesion is associated
with a single morbidity risk figure in computing familial risk figures, especially when these …