Schizandrin B attenuates hypoxia/reoxygenation injury in H9c2 cells by activating the AMPK/Nrf2 signaling pathway

B Zhao, GP Li, JJ Peng, LH Ren… - Experimental and …, 2021 - spandidos-publications.com
Schizandrin B exhibits prominent antioxidant and anti-inflammatory effects, and plays an
important role in ameliorating myocardial ischemia/reperfusion injury. However, the …

Schisandrin B Ameliorates Myocardial Ischemia/Reperfusion Injury Through Attenuation of Endoplasmic Reticulum Stress-Induced Apoptosis

W Zhang, Z Sun, F Meng - Inflammation, 2017 - Springer
Abstract Schisandrin B (Sch B), an active composition isolated from the fruit of Schisandra
chinensis, has been proved to possess antiinflammatory, antioxidant and anti-endoplasmic …

Beneficial effects of schisandrin B on the cardiac function in mice model of myocardial infarction

P Chen, S Pang, N Yang, H Meng, J Liu, N Zhou… - PloS one, 2013 - journals.plos.org
The fruit of Schisandra chinensis has been used in the traditional Chinese medicine for
thousands of years. Accumulating evidence suggests that Schisandrin B (Sch B) has …

Schisandrin B Prevents Hind Limb from Ischemia‐Reperfusion‐Induced Oxidative Stress and Inflammation via MAPK/NF‐κB Pathways in Rats

N Zhu, C Cai, A Zhou, X Zhao, Y Xiang… - BioMed research …, 2017 - Wiley Online Library
Schisandrin B (ScB), isolated from Schisandra chinensis (S. chinensis), is a traditional
Chinese medicine with proven cardioprotective and neuroprotective effects. However, it is …

Schisandrin B protects against myocardial ischemia/reperfusion injury via the PI3K/Akt pathway in rats

X Zhao, Y Xiang, C Cai, A Zhou… - Molecular Medicine …, 2018 - spandidos-publications.com
The natural medicinal monomer, schisandrin B (Sch B), has been shown to exert
cardioprotective effects; however, the underlying mechanisms of these effects remain to be …

Schisandrin B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK/Nrf2 pathway in H9c2 cells

PY Chiu, N Chen, PK Leong, HY Leung… - Molecular and cellular …, 2011 - Springer
This study investigated the signal transduction pathway involved in the cytoprotective action
of (−) schisandrin B [(−) Sch B, a stereoisomer of Sch B]. Using H9c2 cells, the authors …

Protective effects of safranal on hypoxia/reoxygenation‑induced injury in H9c2 cardiac myoblasts via the PI3K/AKT/GSK3β signaling pathway

H Wang, B Zheng, K Che, X Han… - Experimental and …, 2021 - spandidos-publications.com
Safranal (SFR), an active ingredient extracted from saffron, exhibits a protective effect on the
cardiovascular system. However, the mechanism of SFR against hypoxia/reoxygenation …

Schisandrin A suppresses lipopolysaccharide-induced inflammation and oxidative stress in RAW 264.7 macrophages by suppressing the NF-κB, MAPKs and PI3K/Akt …

DH Kwon, HJ Cha, EO Choi… - International …, 2018 - spandidos-publications.com
Schisandrin A is a bioactive lignan occurring in the fruits of plants of the Schisandra genus
that have traditionally been used in Korea for treating various inflammatory diseases …

[HTML][HTML] Schisandrin A prevents oxidative stress-induced DNA damage and apoptosis by attenuating ROS generation in C2C12 cells

YH Choi - Biomedicine & Pharmacotherapy, 2018 - Elsevier
The generation of excessive reactive oxygen species (ROS) by oxidative stress has various
deleterious effects on cellular constituents. Therefore, the discovery of natural products that …

[HTML][HTML] Schizandrin A protects against cerebral ischemia-reperfusion injury by suppressing inflammation and oxidative stress and regulating the AMPK/Nrf2 pathway …

F Zhou, M Wang, J Ju, Y Wang, Z Liu… - American Journal of …, 2019 - ncbi.nlm.nih.gov
Inflammation and oxidative stress are considered major factors in the pathogenesis of
ischemic stroke. Increasing evidence has demonstrated that Schizandrin A (Sch A), a lignin …