For those using drugs to treat infants and children, the integration of developmental
pharmacology is crucial to appropriate clinical practice. Changes in metabolic capacity …

Providing safe and effective drug therapy to neonates requires knowledge of the impact of
development on the pharmacokinetics and pharmacodynamics of drugs. Although …

The data guiding the dosing, efficacy and safety of medicines for children have lagged
substantially as compared to the information available for adults. As a consequence …

Effective drug therapy to optimally influence disease requires an understanding of a drug's
pharmacokinetic, pharmacodynamic, and pharmacogenomic interrelationships. In …

Information on drug absorption and disposition in infants and children has increased
considerably over the past 2 decades. However, the impact of specific age-related effects on …

In addition to differences in the pharmacodynamic response in the infant, the dose and the
pharmacokinetic processes acting upon that dose principally determine the efficacy and/or …

Knowledge about the safe and effective use of medicines in neonates has increased
substantially but has resulted in few label changes. Drugs developed for use in adults are …

Drug metabolism importantly determines drug concentrations. The efficacy and safety of
many drugs prescribed for children are, therefore, dependent on intraindividual and …

Rational pharmacotherapy is dependent upon an understanding of the clinical
pharmacokinetic and pharmacodynamic properties of the drugs employed. Although the …

Pharmacokinetic data reported during the past two decades clearly demonstrate that
development markedly influences the absorption, distribution, excretion, and metabolism of …