The molecular biology of head and neck cancer

CR Leemans, BJM Braakhuis, RH Brakenhoff - Nature reviews cancer, 2011 - nature.com
Head and neck squamous cell carcinomas (HNSCCs) are caused by tobacco and alcohol
consumption and by infection with high-risk types of human papillomavirus (HPV). Tumours …

[HTML][HTML] Epigenetic modifications and head and neck cancer: implications for tumor progression and resistance to therapy

RM Castilho, CH Squarize, LO Almeida - International journal of …, 2017 - mdpi.com
Head and neck squamous carcinoma (HNSCC) is the sixth most prevalent cancer and one
of the most aggressive malignancies worldwide. Despite continuous efforts to identify …

[HTML][HTML] Molecular landscape of head and neck cancer and implications for therapy

CS Farah - Annals of Translational Medicine, 2021 - ncbi.nlm.nih.gov
Head and neck squamous cell carcinomas (HNSCC) arising from the oral cavity, pharynx,
and larynx constitute the 6 th most common human cancer. Human papillomavirus (HPV) …

[HTML][HTML] Clinical update on head and neck cancer: molecular biology and ongoing challenges

E Alsahafi, K Begg, I Amelio, N Raulf, P Lucarelli… - Cell death & …, 2019 - nature.com
Head and neck squamous cell carcinomas (HNSCCs) are an aggressive, genetically
complex and difficult to treat group of cancers. In lieu of truly effective targeted therapies …

The molecular pathogenesis of head and neck cancer

JD Klein, JR Grandis - Cancer biology & therapy, 2010 - Taylor & Francis
Head and neck cancer arises from a series of molecular alterations progressive from
dysplasia to carcinoma in situ, and finally invasive carcinoma. Risk factors associated with …

Head and neck cancer: from anatomy to biology

P Bose, NT Brockton, JC Dort - International journal of cancer, 2013 - Wiley Online Library
The 20th century saw great advances in anatomy‐based (surgery and radiotherapy) and
chemotherapy approaches for treating head and neck squamous cell carcinoma (HNSCC) …

[HTML][HTML] Targeted therapy for head and neck cancer: signaling pathways and clinical studies

Q Li, Y Tie, A Alu, X Ma, H Shi - Signal transduction and targeted …, 2023 - nature.com
Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …

[HTML][HTML] The molecular pathogenesis of head and neck squamous cell carcinoma

SM Rothenberg, LW Ellisen - The Journal of clinical …, 2012 - Am Soc Clin Investig
Squamous cell carcinoma of the head and neck (HNSCC) is a relatively common human
cancer characterized by high morbidity, high mortality, and few therapeutic options outside …

Applying the molecular biology and epigenetics of head and neck cancer in everyday clinical practice

CA Glazer, SS Chang, PK Ha, JA Califano - Oral oncology, 2009 - Elsevier
During the past decade, there has been a significant increase in knowledge regarding the
molecular biology and epigenetics of head and neck squamous cell carcinoma (HNSCC) …

[PDF][PDF] Molecular pathways in head and neck cancer: EGFR, PI3K, and more

A Psyrri, TY Seiwert, A Jimeno - American Society of Clinical …, 2013 - ascopubs.org
The treatment of head and neck squamous cell carcinoma (HNSCC) is set to undergo rapid
changes, as novel treatment targets informed by genomic profiling and novel molecularly …