Extrusion of drugs or drug-like compounds through bacterial efflux pumps is a serious health
issue that leads to loss in drug efficacy. Combinatorial therapies of low-efficacy drugs with …

The essential oil carvacrol from oregano displays a wide range of biological activities among
which is found the inhibition of efflux pumps. Thus, using carvacrol, the current work …

Drug efflux pumps confer resistance upon bacteria to a wide range of antibiotics from
various classes. The expression of efflux pumps are also implicated in virulence and biofilm …

Antibiotics, once considered the lifeline for treating bacterial infections, are under threat due
to the emergence of threatening antimicrobial resistance (AMR). These drug-resistant …

As part of an ongoing project to identify plant natural products as efflux pump inhibitors
(EPIs), bioassay-guided fractionation of the methanolic extract of Mirabilis jalapa …

Infections by Gram-negative pathogens are usually difficult to manage due to the drug export
by efflux pumps. With the evolution and horizontal transfer of efflux pumps, there is an urgent …

Drug efflux pumps confer multidrug resistance to dangerous pathogens which makes these
pumps important drug targets. We have synthesised a novel series of compounds based on …

Managing antibiotic resistance is a significant challenge in modern pharmacotherapy. While
molecular analyses have identified efflux pump expression as an essential mechanism …

Multidrug efflux is a major contributor to antibiotic resistance in Gram-negative bacterial
pathogens. Inhibition of multidrug efflux pumps is a promising approach for reviving the …

Efflux is an important mechanism in Gram-negative bacteria conferring multidrug resistance.
Inhibition of efflux is an encouraging strategy to restore the antibacterial activity of antibiotics …